- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Kuhn, D. T.
- Articles by Packert, G.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Kuhn, D. T.
- Articles by Packert, G.
Genetics, Vol 133, 593-604, Copyright © 1993
INVESTIGATIONS |
Tumorous-head (tuh-1; tuh-3) Modulates Abd-B Bithorax-Complex Functions in Drosophila melanogaster
D. T. Kuhn, J. A. Mack, C. Duan and G. Packert
Department of Biology, University of Central Florida, Orlando, Florida 32816
Abdominal-B (Abd-B) mutants of the bithorax-complex (BX-C) were studied in trans with tuh-3 to evaluate their interactions with this homeotic mutant and the maternal effect locus (tuh-1) controlling tuh-3 expression. Head defects occur in tuh-3 offspring from tuh-1(h) homozygous mothers, while genital defects occur in homozygous tuh-3 offspring from mothers carrying the tuh-1(g) allele. The influence exerted by the tuh-1 maternal effects on tuh-3 Abd-B transcript distribution was evaluated by whole mount in situ hybridization. Results demonstrated that: (1) of the 21 Abd-B mutants tested, head defects were produced by SGA62, I127(B), I127(o) and tuh-3, with I127(B) and tuh-3 as the only mutants to require the head defect maternal effect for expression; (2) one specific cluster of regulatory (r) mutants, Uab(1), 65 and I127(B), enhanced penetrance and expressivity of tuh-3 head defects; (3) the most profound suppression of head defect penetrance occurred when Abd-B mutants eliminated the morphogenetic (m) and r functions; (4) genital defects increased in frequency in tuh-3/Abd-B mutant trans-heterozygotes with loss of r function; (5) Abd-B transcription (class A, class B, class C) appears normal in tuh-3 embryos when their mothers pass on the tuh-1(h) head defect maternal effect, whereas the regulatory transcripts (class B and class C) are reduced when tuh-3 mothers pass on the tuh-1(g) genital disc maternal effect; (5) tuh eye-antennal imaginal discs express ABD-B protein; and (6) tuh-3 misregulates both m and r function of Abd-B.
This article has been cited by other articles:
 |
|
 |
|
  F. Prince, T. Katsuyama, Y. Oshima, S. Plaza, D. Resendez-Perez, M. Berry, S. Kurata, and W. J. Gehring The YPWM motif links Antennapedia to the basal transcriptional machinery Development, May 1, 2008; 135(9): 1669 - 1679. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Bender MicroRNAs in the Drosophila bithorax complex Genes & Dev., January 1, 2008; 22(1): 14 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Packert and D. T. Kuhn The tumorous-head-1 Locus Affects Bristle Number of the Drosophila melanogaster Cuticle Genetics, February 1, 1998; 148(2): 743 - 752. [Abstract] [Full Text] [PDF]
|
|