Preferential Transposition of Drosophila P Elements to Nearby Chromosomal Sites

INVESTIGATIONS

Preferential Transposition of Drosophila P Elements to Nearby Chromosomal Sites

J. Tower, G. H. Karpen, N. Craig and A. C. Spradling
Present address: Department of Biological Sciences, University of Southern California, University Park, Los Angeles, California 90089.

Two different schemes were used to demonstrate that Drosophila P elements preferentially transpose into genomic regions close to their starting sites. A starting element with weak rosy(+) marker gene expression was mobilized from its location in the subtelomeric region of the 1,300-kb Dp1187 minichromosome. Among progeny lines with altered rosy(+) expression, a much higher than expected frequency contained new insertions on Dp1187. Terminal deficiencies were also recovered frequently. In a second screen, a rosy(+)-marked element causing a lethal mutation of the cactus gene was mobilized in male and female germlines, and viable revertant chromosomes were recovered that still contained a rosy(+) gene due to an intrachromosomal transposition. New transpositions recovered using both methods were mapped between 0 and 128 kb from the starting site. Our results suggested that some mechanism elevates the frequency 43-67-fold with which a P element inserts near its starting site. Local transposition is likely to be useful for enhancing the rate of insertional mutation within predetermined regions of the genome.

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				M. Nozawa, M. Kumagai, T. Aotsuka, and K. Tamura Unusual Evolution of Interspersed Repeat Sequences in the Drosophila ananassae Subgroup Mol. Biol. Evol., May 1, 2006; 23(5): 981 - 987. [Abstract] [Full Text] [PDF]

				E. P. Hamilton, S. Williamson, S. Dunn, V. Merriam, C. Lin, L. Vong, J. Russell-Colantonio, and E. Orias The Highly Conserved Family of Tetrahymena thermophila Chromosome Breakage Elements Contains an Invariant 10-Base-Pair Core. Eukaryot. Cell, April 1, 2006; 5(4): 771 - 780. [Abstract] [Full Text] [PDF]

				E. Pomerantseva, I. Biryukova, R. Silicheva, E. Savitskaya, A. Golovnin, and P. Georgiev Transposition of Regulatory Elements by P-Element-Mediated Rearrangements in Drosophila melanogaster Genetics, April 1, 2006; 172(4): 2283 - 2291. [Abstract] [Full Text] [PDF]

				J. A. Sved and X. Liang Evidence of P-Element-Induced Sister-Chromatid Exchange in a Ring-X Chromosome in Drosophila, With Implication for a High Rate of Formation of Hybrid Elements Genetics, February 1, 2006; 172(2): 975 - 979. [Abstract] [Full Text] [PDF]

				M. D. Drapeau, S. A. Cyran, M. M. Viering, P. K. Geyer, and A. D. Long A cis-regulatory Sequence Within the yellow Locus of Drosophila melanogaster Required for Normal Male Mating Success Genetics, February 1, 2006; 172(2): 1009 - 1030. [Abstract] [Full Text] [PDF]

				M. C. van der Plas, G. S. K. Pilgram, J. J. Plomp, A. de Jong, L. G. Fradkin, and J. N. Noordermeer Dystrophin Is Required for Appropriate Retrograde Control of Neurotransmitter Release at the Drosophila Neuromuscular Junction J. Neurosci., January 4, 2006; 26(1): 333 - 344. [Abstract] [Full Text] [PDF]

				S. R. Yant, X. Wu, Y. Huang, B. Garrison, S. M. Burgess, and M. A. Kay High-Resolution Genome-Wide Mapping of Transposon Integration in Mammals Mol. Cell. Biol., March 15, 2005; 25(6): 2085 - 2094. [Abstract] [Full Text] [PDF]

				B. T. Sage, J. L. Jones, A. L. Holmes, M. D. Wu, and A. K. Csink Sequence Elements in cis Influence Heterochromatic Silencing in trans Mol. Cell. Biol., January 1, 2005; 25(1): 377 - 388. [Abstract] [Full Text] [PDF]

				K. Lipkow, N. Buisine, and R. Chalmers Promiscuous Target Interactions in the mariner Transposon Himar1 J. Biol. Chem., November 19, 2004; 279(47): 48569 - 48575. [Abstract] [Full Text] [PDF]

				J. M. Mason, J. Ransom, and A. Y. Konev A Deficiency Screen for Dominant Suppressors of Telomeric Silencing in Drosophila Genetics, November 1, 2004; 168(3): 1353 - 1370. [Abstract] [Full Text] [PDF]

				M. Hiller, X. Chen, M. J. Pringle, M. Suchorolski, Y. Sancak, S. Viswanathan, B. Bolival, T.-Y. Lin, S. Marino, and M. T. Fuller Testis-specific TAF homologs collaborate to control a tissue-specific transcription program Development, November 1, 2004; 131(21): 5297 - 5308. [Abstract] [Full Text] [PDF]

				S. R. Oikemus, N. McGinnis, J. Queiroz-Machado, H. Tukachinsky, S. Takada, C. E. Sunkel, and M. H. Brodsky Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect Genes & Dev., August 1, 2004; 18(15): 1850 - 1861. [Abstract] [Full Text] [PDF]

				H. J. Bellen, R. W. Levis, G. Liao, Y. He, J. W. Carlson, G. Tsang, M. Evans-Holm, P. R. Hiesinger, K. L. Schulze, G. M. Rubin, et al. The BDGP Gene Disruption Project: Single Transposon Insertions Associated With 40% of Drosophila Genes Genetics, June 1, 2004; 167(2): 761 - 781. [Abstract] [Full Text] [PDF]

				S. Onel, L. Bolke, and C. Klambt The Drosophila ARF6-GEF Schizo controls commissure formation by regulating Slit Development, June 1, 2004; 131(11): 2587 - 2594. [Abstract] [Full Text] [PDF]

				A. Y. Konev, C. M. Yan, D. Acevedo, C. Kennedy, E. Ward, A. Lim, S. Tickoo, and G. H. Karpen Genetics of P-Element Transposition Into Drosophila melanogaster Centric Heterochromatin Genetics, December 1, 2003; 165(4): 2039 - 2053. [Abstract] [Full Text] [PDF]

				C. M. Carlson, A. J. Dupuy, S. Fritz, K. J. Roberg-Perez, C. F. Fletcher, and D. A. Largaespada Transposon Mutagenesis of the Mouse Germline Genetics, September 1, 2003; 165(1): 243 - 256. [Abstract] [Full Text] [PDF]

				T. Yamada, M. Okabe, and Y. Hiromi EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed Development, September 1, 2003; 130(17): 4085 - 4096. [Abstract] [Full Text] [PDF]

				S. E. J. Fischer, E. Wienholds, and R. H. A. Plasterk Continuous Exchange of Sequence Information Between Dispersed Tc1 Transposons in the Caenorhabditis elegans Genome Genetics, May 1, 2003; 164(1): 127 - 134. [Abstract] [Full Text] [PDF]

				A. Boivin, C. Gally, S. Netter, D. Anxolabehere, and S. Ronsseray Telomeric Associated Sequences of Drosophila Recruit Polycomb-Group Proteins in Vivo and Can Induce Pairing-Sensitive Repression Genetics, May 1, 2003; 164(1): 195 - 208. [Abstract] [Full Text] [PDF]

				W. Boll and M. Noll The Drosophila Pox neuro gene: control of male courtship behavior and fertility as revealed by a complete dissection of all enhancers Development, March 14, 2003; 129(24): 5667 - 5681. [Abstract] [Full Text] [PDF]

				J. M. Mason, A. Y. Konev, M. D. Golubovsky, and H. Biessmann Cis- and trans-acting Influences on Telomeric Position Effect in Drosophila melanogaster Detected With a Subterminal Transgene Genetics, March 1, 2003; 163(3): 917 - 930. [Abstract] [Full Text] [PDF]