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Genetics, Vol 133, 237-245, Copyright © 1993
INVESTIGATIONS |
Post-Transcriptional Regulation of RNA Polymerase II Levels in Caenorhabditis elegans
B. K. Dalley, T. M. Rogalski, G. E. Tullis, D. L. Riddle and M. Golomb
Current address: Department of Molecular Microbiology and Immunology, University of Missouri-Columbia, Columbia, Missouri 65212.
To investigate the regulation of RNA polymerase II levels in Caenorhabditis elegans, we have constructed nematode strains having one, two, or three copies of ama-1, the gene for the largest subunit of RNA polymerase II. Steady-state levels of RNA polymerase II polypeptides and solubilized enzyme activity are invariant with gene dosage, indicating regulatory compensation. However, steady-state levels of ama-1 mRNA are directly proportional to gene dosage. These results imply that RNA polymerase II levels in C. elegans are regulated post-transcriptionally.
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