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Genetics, Vol 132, 1017-1031, Copyright © 1992
INVESTIGATIONS |
Uniparental Cytogamy: A Novel Method for Bringing Micronuclear Mutations of Tetrahymena into Homozygous Macronuclear Expression With Precocious Sexual Maturity
E. S. Cole and P. J. Bruns
Department of Genetics and Development, Cornell University, Ithaca, New York 14853.
A new method of inducing self-fertilization, uniparental cytogamy, yields homozygous germinal and somatic genotypes in the ciliate Tetrahymena thermophila. Progeny are highly fertile and show a marked tendency for precocious sexual maturity. This method is highly effective in protocols designed to generate and express nonlethal dominant or recessive mutations.
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