- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Stephan, W.
- Articles by Langley, C. H.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Stephan, W.
- Articles by Langley, C. H.
Genetics, Vol 132, 567-574, Copyright © 1992
INVESTIGATIONS |
Evolutionary Consequences of DNA Mismatch Inhibited Repair Opportunity
W. Stephan and C. H. Langley
Department of Zoology, University of Maryland, College Park, Maryland 20742
Double strand breaks (DSBs) are often repaired via homologous recombination. Recombinational repair processes are expected to be influenced by nucleotide heterozygosity through mismatch detection systems. Unrepaired DSBs have severe biological consequences and are often lethal. We show that natural selection due to inhibition of recombinational repair associated with polymorphisms could influence their molecular evolution. The main conclusions from this analysis are that, for increasing population size, mismatch detection leads to a limit on average heterozygosity of otherwise selectively neutral polymorphism, an excess of rare variants, and a slowing down of the rate of neutral molecular evolution. The first two results suggest that mismatch detection may account for the surprisingly narrow range of observed average heterozygosities, given the great variation in population size between species.
This article has been cited by other articles:
 |
|
 |
|
  P. Andolfatto and J. D. Wall Linkage Disequilibrium Patterns Across a Recombination Gradient in African Drosophila melanogaster Genetics, November 1, 2003; 165(3): 1289 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Langley, B. P. Lazzaro, W. Phillips, E. Heikkinen, and J. M. Braverman Linkage Disequilibria and the Site Frequency Spectra in the su(s) and su(wa) Regions of the Drosophila melanogaster X Chromosome Genetics, December 1, 2000; 156(4): 1837 - 1852. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Laroche, P. Li, L. Maggia, and J. Bousquet Molecular evolution of angiosperm mitochondrial introns and exons PNAS, May 27, 1997; 94(11): 5722 - 5727. [Abstract] [Full Text] [PDF]
|
|