Seven Genes of the Enhancer of split Complex of Drosophila melanogaster Encode Helix-Loop-Helix Proteins

INVESTIGATIONS

Seven Genes of the Enhancer of split Complex of Drosophila melanogaster Encode Helix-Loop-Helix Proteins

E. Knust, H. Schrons, F. Grawe and J. A. Campos-Ortega
Institut fur Entwicklungsbiologie, Universitat zu Koln, 5000 Koln 41, Germany

Enhancer of split [E(spl)] is one of the neurogenic loci of Drosophila and, as such, is required for normal segregation of neural and epidermal cell progenitors. Genetic observations indicate that the E(spl) locus is in fact a gene complex comprising a cluster of related genes and that other genes of the region are also required for normal early neurogenesis. Three of the genes of the complex were known to encode helix-loop-helix (HLH) proteins and to be transcribed in nearly identical patterns. Here, we show that four other genes in the vicinity also encode HLH proteins and, during neuroblast segregation, three of them are expressed in the same pattern. We show by germ-line transformation that these three genes are also necessary to allow epidermal development of the neuroectodermal cells.

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				B. H. Jennings, D. M. Tyler, and S. J. Bray Target Specificities of Drosophila Enhancer of split Basic Helix-Loop-Helix Proteins Mol. Cell. Biol., July 1, 1999; 19(7): 4600 - 4610. [Abstract] [Full Text] [PDF]

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				A Jazwinska, C Rushlow, and S Roth The role of brinker in mediating the graded response to Dpp in early Drosophila embryos Development, January 8, 1999; 126(15): 3323 - 3334. [Abstract] [PDF]

				C Takke and J. Campos-Ortega her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development Development, January 7, 1999; 126(13): 3005 - 3014. [Abstract] [PDF]

				C Takke, P Dornseifer, E v Weizsacker, and J. Campos-Ortega her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling Development, January 5, 1999; 126(9): 1811 - 1821. [Abstract] [PDF]

				H. K. Kim and G. Siu The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression Mol. Cell. Biol., December 1, 1998; 18(12): 7166 - 7175. [Abstract] [Full Text] [PDF]

				G. Chen, P. H. Nguyen, and A. J. Courey A Role for Groucho Tetramerization in Transcriptional Repression Mol. Cell. Biol., December 1, 1998; 18(12): 7259 - 7268. [Abstract] [Full Text] [PDF]

				M. Fostier, D. A. P. Evans, S. Artavanis-Tsakonas, and M. Baron Genetic Characterization of the Drosophila melanogaster Suppressor of deltex Gene: A Regulator of Notch Signaling Genetics, December 1, 1998; 150(4): 1477 - 1485. [Abstract] [Full Text]

				K Dumstrei, C Nassif, G Abboud, A Aryai, A Aryai, and V Hartenstein EGFR signaling is required for the differentiation and maintenance of neural progenitors along the dorsal midline of the Drosophila embryonic head Development, January 9, 1998; 125(17): 3417 - 3426. [Abstract] [PDF]

				P Ligoxygakis, S. Yu, C Delidakis, and N. Baker A subset of notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex Development, January 8, 1998; 125(15): 2893 - 2900. [Abstract] [PDF]

				A. Strom, P. Castella, J. Rockwood, J. Wagner, and M. Caudy Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation Genes & Dev., December 1, 1997; 11(23): 3168 - 3181. [Abstract] [Full Text] [PDF]