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Genetics, Vol 131, 917-927, Copyright © 1992
INVESTIGATIONS |
A P Element Chimera Containing Captured Genomic Sequences Was Recovered at the vestigial Locus in Drosophila Following Targeted Transposition
T. R. Heslip, J. A. Williams, J. B. Bell and R. B. Hodgetts
Department of Genetics, University of Alberta, Edmonton, Alberta, Canada, T6G 2E9
A P element carrying the Dopa decarboxylase gene, P[Ddc], was targeted into vg(21), a cryptic P element induced mutant allele of the vestigial (vg) locus. The resulting allele, vg(28w), contained the expected P[Ddc] plus an additional 9.5 kb of DNA, captured from elsewhere on chromosome II. Reversion of the vg(28w) mutant allele demonstrated that the entire insert can excise but cannot reinsert at an appreciable frequency. We explain the targeted transposition as the repair of a double stranded gap, created by the excision of the P element at vg(21), and suggest that the formation of chimeric elements may be an important component of P element dependent genomic instability.
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