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Genetics, Vol 131, 895-903, Copyright © 1992
INVESTIGATIONS |
Mutations in the Second-Largest Subunit of Drosophila RNA Polymerase II Interact with Ubx
M. A. Mortin, R. Zuerner, S. Berger and B. J. Hamilton
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
Specific mutations in the gene encoding the largest subunit of RNA polymerase II (RpII215) cause a partial transformation of a structure of the third thoracic segment, the capitellum, into the analogous structure of the second thoracic segment, the wing. This mutant phenotype is also caused by genetically reducing the cellular concentration of the transcription factor Ultrabithorax (Ubx). To recover mutations in the 140,000-D second-largest subunit of RNA polymerase II (RpII140) and determine whether any can cause a mutant phenotype similar to Ubx we attempted to identify all recessive-lethal mutable loci in a 340-kilobase deletion including this and other loci. One of the 13 complementation groups in this region encodes RpII140. Three RpII140 alleles cause a transformation of capitellum to wing but unlike RpII215 alleles, only when the concentration of Ubx protein is reduced by mutations in Ubx.
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