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Genetics, Vol 131, 643-653, Copyright © 1992
INVESTIGATIONS |
Use of a Yeast Site-Specific Recombinase to Produce Female Germline Chimeras in Drosophila
T. B. Chou and N. Perrimon
Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
We describe an efficient method for generating female germline mosaics by inducing site-specific homologous mitotic recombination with a yeast recombinase (FLP) which is driven by a heat shock promoter. These germline mosaics are produced in flies heterozygous for the agametic, germline-dependent, dominant female sterile (DFS) mutation ovo(D1), where only flies possessing germline clones are able to lay eggs. This method, the ``FLP-DFS'' technique, is very efficient because more than 90% of females with germline clones can be recovered. We show that this heat-inducible, site-specific mitotic recombination system does not affect viability and that the germline clones recovered are physiologically the same as those created by X-ray induced mitotic recombination. We describe the parameters of FLP-recombinase induced germline mitotic recombination and the use of the ``FLP-DFS'' technique to analyze the maternal effect of X-linked zygotic lethal mutations.
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C SchuLtt, A Hilfiker, and R Nothiger virilizer regulates Sex-lethal in the germline of Drosophila melanogaster Development, January 4, 1998; 125(8): 1501 - 1507. [Abstract] [PDF] |
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H. Broihier, L. Moore, M Van Doren, S Newman, and R Lehmann zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila Development, January 2, 1998; 125(4): 655 - 666. [Abstract] [PDF] |
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A Forbes and R Lehmann Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells Development, January 2, 1998; 125(4): 679 - 690. [Abstract] [PDF] |
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X Li, M. Graner, E. Williams, C. Roote, T. Bunch, and S Zusman Requirements for the cytoplasmic domain of the alphaPS1, alphaPS2 and betaPS integrin subunits during Drosophila development Development, January 2, 1998; 125(4): 701 - 711. [Abstract] [PDF] |
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J. E. Treisman, A. Luk, G. M. Rubin, and U. Heberlein eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins Genes & Dev., August 1, 1997; 11(15): 1949 - 1962. [Abstract] [Full Text] [PDF] |
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