Genetics, Vol 131, 609-624, Copyright © 1992

INVESTIGATIONS

A Genetic Mapping System in Caenorhabditis elegans Based on Polymorphic Sequence-Tagged Sites

B. D. Williams, B. Schrank, C. Huynh, R. Shownkeen and R. H. Waterston
Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110

We devised an efficient genetic mapping system in the nematode Caenorhabditis elegans which is based upon the differences in number and location of the transposable element Tc1 between the Bristol and Bergerac strains. Using the nearly completed physical map of the C. elegans genome, we selected 40 widely distributed sites which contain a Tc1 element in the Bergerac strain, but not in the Bristol strain. For each site a polymerase chain reaction assay was designed that can distinguish between the Bergerac Tc1-containing site and the Bristol ``empty'' site. By combining appropriate assays in a single reaction, one can score multiple sites within single worms. This permits a mutation to be rapidly mapped, first to a linkage group and then to a chromosomal subregion, through analysis of only a small number of progeny from a single interstrain cross.


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M Boxem, D. Srinivasan, and S van den Heuvel
The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase
Development, January 5, 1999; 126(10): 2227 - 2239.
[Abstract] [PDF]

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 DevelopmentHome page
R Baran, R Aronoff, and G Garriga
The C. elegans homeodomain gene unc-42 regulates chemosensory and glutamate receptor expression
Development, January 5, 1999; 126(10): 2241 - 2251.
[Abstract] [PDF]

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 DevelopmentHome page
H Tabara, R. Hill, C. Mello, J. Priess, and Y Kohara
pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans
Development, January 1, 1999; 126(1): 1 - 11.
[Abstract] [PDF]

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 DevelopmentHome page
J. Maloof, J Whangbo, J. Harris, G. Jongeward, and C Kenyon
A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans
Development, January 1, 1999; 126(1): 37 - 49.
[Abstract] [PDF]

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 Genome ResHome page
D. Pilgrim
CeRep25B Forms Chromosome-Specific Minisatellite Arrays in Caenorhabditis elegans
Genome Res., November 1, 1998; 8(11): 1192 - 1201.
[Abstract] [Full Text]

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 Proc. Natl. Acad. Sci. USAHome page
M. Take-uchi, M. Kawakami, T. Ishihara, T. Amano, K. Kondo, and I. Katsura
An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans
PNAS, September 29, 1998; 95(20): 11775 - 11780.
[Abstract] [Full Text] [PDF]

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 ScienceHome page
L. S. Nelson, M. L. Rosoff, and C. Li
Disruption of a Neuropeptide Gene, flp-1, Causes Multiple Behavioral Defects in Caenorhabditis elegans
Science, September 11, 1998; 281(5383): 1686 - 1690.
[Abstract] [Full Text]

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 GeneticsHome page
M. R. Lackner and S. K. Kim
Genetic Analysis of the Caenorhabditis elegans MAP Kinase Gene mpk-1
Genetics, September 1, 1998; 150(1): 103 - 117.
[Abstract] [Full Text]

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 GeneticsHome page
D. Gems, A. J. Sutton, M. L. Sundermeyer, P. S. Albert, K. V. King, M. L. Edgley, P. L. Larsen, and D. L. Riddle
Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans
Genetics, September 1, 1998; 150(1): 129 - 155.
[Abstract] [Full Text]

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 GeneticsHome page
D. Jacobs, G. J. Beitel, S. G. Clark, H. R. Horvitz, and K. Kornfeld
Gain-of-Function Mutations in the Caenorhabditis elegans lin-1 ETS Gene Identify a C-Terminal Regulatory Domain Phosphorylated by ERK MAP Kinase
Genetics, August 1, 1998; 149(4): 1809 - 1822.
[Abstract] [Full Text] [PDF]

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 Mol. Biol. CellHome page
W. B. Raich, A. N. Moran, J. H. Rothman, and J. Hardin
Cytokinesis and Midzone Microtubule Organization in Caenorhabditis elegans Require the Kinesin-like Protein ZEN-4
Mol. Biol. Cell, August 1, 1998; 9(8): 2037 - 2049.
[Abstract] [Full Text]

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 Proc. Natl. Acad. Sci. USAHome page
S. Rajaram, M. M. Sedensky, and P. G. Morgan
unc-1: A stomatin homologue controls sensitivity to volatile anesthetics in Caenorhabditis elegans
PNAS, July 21, 1998; 95(15): 8761 - 8766.
[Abstract] [Full Text] [PDF]

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 GeneticsHome page
J. E. Abrahante, E. A. Miller, and A. E. Rougvie
Identification of Heterochronic Mutants in Caenorhabditis elegans: Temporal Misexpression of a Collagen::Green Fluorescent Protein Fusion Gene
Genetics, July 1, 1998; 149(3): 1335 - 1351.
[Abstract] [Full Text] [PDF]

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 GeneticsHome page
D. Hansen and D. Pilgrim
Molecular Evolution of a Sex Determination Protein: FEM-2 (PP2C) in Caenorhabditis
Genetics, July 1, 1998; 149(3): 1353 - 1362.
[Abstract] [Full Text] [PDF]

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 JCBHome page
L. R. Matthews, P. Carter, D. Thierry-Mieg, and K. Kemphues
ZYG-9, A Caenorhabditis elegans Protein Required for Microtubule Organization and Function, Is a Component of Meiotic and Mitotic Spindle Poles
J. Cell Biol., June 1, 1998; 141(5): 1159 - 1168.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
G. P. Vatcher, C. M. Thacker, T. Kaletta, H. Schnabel, R. Schnabel, and D. L. Baillie
Serine Hydroxymethyltransferase Is Maternally Essential in Caenorhabditis elegans
J. Biol. Chem., March 13, 1998; 273(11): 6066 - 6073.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
L. Rose and K Kemphues
The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo
Development, January 4, 1998; 125(7): 1337 - 1346.
[Abstract] [PDF]

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 J. Neurosci.Home page
M. L. Nonet, O. Saifee, H. Zhao, J. B. Rand, and L. Wei
Synaptic Transmission Deficits in Caenorhabditis elegans Synaptobrevin Mutants
J. Neurosci., January 1, 1998; 18(1): 70 - 80.
[Abstract] [Full Text] [PDF]

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 GeneticsHome page
Identification of Caenorhabditis elegans Genes Required for Neuronal Differentiation and Migration
Genetics, January 1, 1998; 148(1): 151 - 166.


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 Genes Dev.Home page
J. Zhu, R. J. Hill, P. J. Heid, M. Fukuyama, A. Sugimoto, J. R. Priess, and J. H. Rothman
end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos
Genes & Dev., November 1, 1997; 11(21): 2883 - 2896.
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 Genome ResHome page
D. L. Janke, J. E. Schein, T. Ha, N. W. Franz, N. J. O'Neil, G. P. Vatcher, H. I. Stewart, L. M. Kuervers, D. L. Baillie, and A. M. Rose
Interpreting a Sequenced Genome: Toward a Cosmid Transgenic Library of Caenorhabditis elegans
Genome Res., October 1, 1997; 7(10): 974 - 985.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
J. T. Fleming, M. D. Squire, T. M. Barnes, C. Tornoe, K. Matsuda, J. Ahnn, A. Fire, J. E. Sulston, E. A. Barnard, D. B. Sattelle, et al.
Caenorhabditis elegans Levamisole Resistance Genes lev-1, unc-29, and unc-38 Encode Functional Nicotinic Acetylcholine Receptor Subunits
J. Neurosci., August 1, 1997; 17(15): 5843 - 5857.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
B. van Swinderen, D. R. Shook, R. H. Ebert, V. A. Cherkasova, T. E. Johnson, R. J. S. Reis, and C. M. Crowder
Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans
PNAS, July 22, 1997; 94(15): 8232 - 8237.
[Abstract] [Full Text] [PDF]