Genetics, Vol 131, 423-447, Copyright © 1992

INVESTIGATIONS

A Genetic Map of the Mouse Suitable for Typing Intraspecific Crosses

W. Dietrich, H. Katz, S. E. Lincoln, H. S. Shin, J. Friedman, N. L. Dracopoli and E. S. Lander
Whitehead Institute for Biomedical Research, Cambridge Massachusetts 02142 Center for Genome Research and Department of Biology, Massachusetts Institute of Technology, Cambridge Massachusetts 02139

We report the construction of a genetic linkage map of the mouse, consisting entirely of genetic markers that can be rapidly typed by polymerase chain reaction and that show a high degree of polymorphism among inbred laboratory strains. Specifically, the map contains 317 simple sequence length polymorphisms at an average spacing of 4.3 cM and is detectably linked to approximately 99% of the mouse genome. In typical crosses between inbred laboratory strains, about 50% of the markers are polymorphic, making it straightforward to follow inheritance in almost any cross.

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				G. A. Brockmann, C. S. Haley, U. Renne, S. A. Knott, and M. Schwerin Quantitative Trait Loci Affecting Body Weight and Fatness From a Mouse Line Selected for Extreme High Growth Genetics, September 1, 1998; 150(1): 369 - 381. [Abstract] [Full Text]

				J. Schimenti and M. Bucan Functional Genomics in the Mouse: Phenotype-Based Mutagenesis Screens Genome Res., July 1, 1998; 8(7): 698 - 710. [Abstract] [Full Text]

				E. Robanus-Maandag, M. Dekker, M. van der Valk, M.-L. Carrozza, J.-C. Jeanny, J.-H. Dannenberg, A. Berns, and H. te Riele p107 is a suppressor of retinoblastoma development in pRb-deficient mice Genes & Dev., June 1, 1998; 12(11): 1599 - 1609. [Abstract] [Full Text]

				M. Rhodes, R. Straw, S. Fernando, A. Evans, T. Lacey, A. Dearlove, J. Greystrong, J. Walker, P. Watson, P. Weston, et al. A High-Resolution Microsatellite Map of the Mouse Genome Genome Res., May 1, 1998; 8(5): 531 - 542. [Abstract] [Full Text]

				J. Q. Feng, X. Luan, J. Wallace, D. Jing, T. Ohshima, A. B. Kulkarni, R. N. D'Souza, C. A. Kozak, and M. MacDougall Genomic Organization, Chromosomal Mapping, and Promoter Analysis of the Mouse Dentin Sialophosphoprotein (Dspp) Gene, Which Codes for Both Dentin Sialoprotein and Dentin Phosphoprotein J. Biol. Chem., April 17, 1998; 273(16): 9457 - 9464. [Abstract] [Full Text] [PDF]

				H. Nakano, S. Mori, H. Yonekawa, H. Nariuchi, A. Matsuzawa, and T. Kakiuchi A Novel Mutant Gene Involved in T-Lymphocyte-Specific Homing Into Peripheral Lymphoid Organs on Mouse Chromosome 4  Blood, April 15, 1998; 91(8): 2886 - 2895. [Abstract] [Full Text] [PDF]

				P. D. Keightley Genetic Basis of Response to 50 Generations of Selection on Body Weight in Inbred Mice Genetics, April 1, 1998; 148(4): 1931 - 1939. [Abstract] [Full Text] [PDF]

				J.-F. Bureau, K. M. Drescher, L. R. Pease, T. Vikoren, M. Delcroix, L. Zoecklein, M. Brahic, and M. Rodriguez Chromosome 14 Contains Determinants That Regulate Susceptibility to Theiler's Virus–Induced Demyelination in the Mouse Genetics, April 1, 1998; 148(4): 1941 - 1949. [Abstract] [Full Text] [PDF]

				Y. Yamada, A. J. Warren, C. Dobson, A. Forster, R. Pannell, and T. H. Rabbitts The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis PNAS, March 31, 1998; 95(7): 3890 - 3895. [Abstract] [Full Text] [PDF]

				J. W. Thomas, C. LaMantia, and T. Magnuson X-ray-induced mutations in mouse embryonic stem cells PNAS, February 3, 1998; 95(3): 1114 - 1119. [Abstract] [Full Text] [PDF]

				V. L. Meiner, C. L. Welch, S. Cases, H. M. Myers, E. Sande, A. J. Lusis, and R. V. Farese Jr. Adrenocortical Lipid Depletion Gene (ald) in AKR Mice Is Associated with an Acyl-CoA:Cholesterol Acyltransferase (ACAT) Mutation J. Biol. Chem., January 9, 1998; 273(2): 1064 - 1069. [Abstract] [Full Text] [PDF]

				K. Latham and C Sapienza Localization of genes encoding egg modifiers of paternal genome function to mouse chromosomes one and two Development, January 3, 1998; 125(5): 929 - 935. [Abstract] [PDF]

				H. S. A. van Schaick, M. P. Smidt, A. C. Rovescalli, M. Luijten, A. A. M. van der Kleij, S. Asoh, C. A. Kozak, M. Nirenberg, and J. P. H. Burbach Homeobox gene Prx3 expression in rodent brain and extraneural tissues PNAS, November 25, 1997; 94(24): 12993 - 12998. [Abstract] [Full Text] [PDF]

				N. C. Nicolaides, K. J. Holroyd, S. L. Ewart, S. M. Eleff, M. B. Kiser, C. R. Dragwa, C. D. Sullivan, L. Grasso, L.-Y. Zhang, C. J. Messler, et al. Interleukin 9: A candidate gene for asthma PNAS, November 25, 1997; 94(24): 13175 - 13180. [Abstract] [Full Text] [PDF]

				B. A. Mock, J. Hartley, P. Le Tissier, J. S. Wax, and M. Potter The Plasmacytoma Resistance Gene, Pctr2, Delays the Onset of Tumorigenesis and Resides in the Telomeric Region of Chromosome 4  Blood, November 15, 1997; 90(10): 4092 - 4098. [Abstract] [Full Text] [PDF]

				J. S. Mogil, S. P. Richards, L. A. O'Toole, M. L. Helms, S. R. Mitchell, B. Kest, and J. K. Belknap Identification of a Sex-Specific Quantitative Trait Locus Mediating Nonopioid Stress-Induced Analgesia in Female Mice J. Neurosci., October 15, 1997; 17(20): 7995 - 8002. [Abstract] [Full Text] [PDF]

				O. A. IAKOUBOVA, H. DUSHKIN, and D. R. BEIER Genetic Analysis of a Quantitative Trait in a Mouse Model of Polycystic Kidney Disease Am. J. Respir. Crit. Care Med., October 1, 1997; 156(4): S72 - S77. [Abstract] [Full Text] [PDF]

				J. S. Fisler and C. H. Warden Mapping of Mouse Obesity Genes: A Generic Approach to a Complex Trait J. Nutr., September 1, 1997; 127(9): 1909 - 1909. [Abstract] [Full Text]

				W. L. Stanford, S. Haque, R. Alexander, X. Liu, A. M. Latour, H. R. Snodgrass, B. H. Koller, and P. M. Flood Altered Proliferative Response by T Lymphocytes of Ly-6A (Sca-1) Null Mice J. Exp. Med., August 29, 1997; 186(5): 705 - 717. [Abstract] [Full Text] [PDF]

				E. H. Radany, K. Hong, S. Kesharvarzi, E. S. Lander, and J. M. Bishop Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4 PNAS, August 5, 1997; 94(16): 8664 - 8669. [Abstract] [Full Text] [PDF]

				B.-S. Youn, S.-H. Kim, M. S. Lyu, C. A. Kozak, D. D. Taub, and B. S. Kwon Molecular Cloning and Characterization of a cDNA, CHEMR1, Encoding a Chemokine Receptor With a Homology to the Human C-C Chemokine Receptor, CCR-4 Blood, June 15, 1997; 89(12): 4448 - 4460. [Abstract] [Full Text] [PDF]