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Genetics, Vol 131, 191-198, Copyright © 1992
INVESTIGATIONS |
Human Population Genetic Studies Using Hypervariable Loci. I. Analysis of Assamese, Australian, Cambodian, Caucasian, Chinese and Melanesian Populations
I. Balazs, J. Neuweiler, P. Gunn, J. Kidd, K. K. Kidd, J. Kuhl and L. Mingjun
Lifecodes Corporation, Valhalla, New York
Population genetic studies, in Australian, Assamese, Cambodian, Chinese, Caucasian and Melanesian populations, were performed with several highly polymorphic DNA loci. Results showed that the Caucasian and Chinese had the highest level of heterozygosity. The size range of the majority of the polymorphic DNA fragments of a locus was the same in the different populations. The distinguishing feature of each ethnic group was the relative frequency of a particular set or group of alleles. For example, alleles >9.0 kb in size, in D14S13, or from 4.5 to 4.7 kb, in D18S27, were less than half as frequent in Caucasians than in the other populations. Overall, there were groups of alleles, at one or more loci, whose frequencies were different among some of the ethnic groups and therefore could be used to differentiate one group from the other.
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