- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Sinclair, DAR.
- Articles by Brock, H. W.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Sinclair, DAR.
- Articles by Brock, H. W.
Genetics, Vol 130, 817-825, Copyright © 1992
INVESTIGATIONS |
Genetic Analysis of the Additional sex combs Locus of Drosophila melanogaster
DAR. Sinclair, R. B. Campbell, F. Nicholls, E. Slade and H. W. Brock
Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
Additional sex combs (Asx) is a member of the Polycomb group of genes, which are thought to be required for maintenance of chromatin structure. To better understand the function of Asx, we have isolated nine new alleles, each of which acts like a gain of function mutation. Asx is required for normal determination of segment identity. Asx(P1) shows an unusual phenotype in that anterior and posterior homeotic transformations are seen in the same individuals, suggesting that Asx(P1) might upset chromatin structure in a way that makes both activation and repression of homeotic genes more difficult. Analysis of embryonic and adult phenotypes of Asx alleles suggests that Asx is required zygotically for determination of segment number and polarity. The expression pattern of even-skipped is altered in Asx mutant embryos, suggesting that Asx is required for normal expression of this gene. We have transposon-tagged the Asx gene, and can thus begin molecular analysis of its function.
This article has been cited by other articles:
 |
|
 |
|
  S. Petruk, S. T. Smith, Y. Sedkov, and A. Mazo Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity Development, July 15, 2008; 135(14): 2383 - 2390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Y. Ali and W. Bender Cross-Regulation among the Polycomb Group Genes in Drosophila melanogaster Mol. Cell. Biol., September 1, 2004; 24(17): 7737 - 7747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Gildea, R. Lopez, and A. Shearn A Screen for New Trithorax Group Genes Identified little imaginal discs, the Drosophila melanogaster Homologue of Human Retinoblastoma Binding Protein 2 Genetics, October 1, 2000; 156(2): 645 - 663. [Abstract] [Full Text]
|
|
|
|
|
|
F Tie, T Furuyama, and P. Harte The Drosophila Polycomb Group proteins ESC and E(Z) bind directly to each other and co-localize at multiple chromosomal sites Development, January 9, 1998; 125(17): 3483 - 3496. [Abstract] [PDF]
|
|
|
|
|
|
D. Sinclair, T. Milne, J. Hodgson, J Shellard, C. Salinas, M Kyba, F Randazzo, and H. Brock The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes Development, January 4, 1998; 125(7): 1207 - 1216. [Abstract] [PDF]
|
|
|
|
|
|
Enhancer of Polycomb Is a Suppressor of Position-Effect Variegation in Drosophila melanogaster Genetics, January 1, 1998; 148(1): 211 - 220.
|
|
|
|
|
|
E. Carrington and R. Jones The Drosophila Enhancer of zeste gene encodes a chromosomal protein: examination of wild-type and mutant protein distribution Development, January 12, 1996; 122(12): 4073 - 4083. [Abstract] [PDF]
|
|
|
|
|
|
I. Sulston and K. Anderson Embryonic patterning mutants of Tribolium castaneum Development, January 3, 1996; 122(3): 805 - 814. [Abstract] [PDF]
|
|