- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Spencer, H. G.
- Articles by Marks, R. W.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Spencer, H. G.
- Articles by Marks, R. W.
Genetics, Vol 130, 211-221, Copyright © 1992
INVESTIGATIONS |
The Maintenance of Single-Locus Polymorphism. IV. Models With Mutation From Existing Alleles
H. G. Spencer and R. W. Marks
Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts 02138, Department of Mathematics and Statistics, University of Waikato, Private Bag 3105, Hamilton, New Zealand Present address and address for correspondence: Department of Mathematics and Statistics, University of Waikato, Private Bag 3105, Hamilton, New Zealand.
The ability of viability selection to maintain allelic polymorphism is investigated using a constructionist approach. In extensions to the models we have previously proposed, a population is bombarded with a series of mutations whose fitnesses in conjunction with other alleles are functions of the corresponding fitnesses with a particular allele, the parent allele, already in the population. Allele frequencies are iterated simultaneously, thus allowing alleles to be driven to extinction by selection. Such models allow very high levels of polymorphism to evolve: up to 38 alleles in one case. Alleles that are lethal as homozygotes can evolve to surprisingly high frequencies. The joint evolution of allele frequencies and viabilities highlights the necessity to consider more than the current morphology of a population. Comparisons are made with the neutral theory of evolution and it is suggested that failure to reject neutrality using the Ewens-Watterson test cannot be regarded as evidence for the neutral theory.
This article has been cited by other articles:
 |
|
 |
|
  R. J. Stoffels and H. G. Spencer An Asymmetric Model of Heterozygote Advantage at Major Histocompatibility Complex Genes: Degenerate Pathogen Recognition and Intersection Advantage Genetics, March 1, 2008; 178(3): 1473 - 1489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Star, R. J. Stoffels, and H. G. Spencer Evolution of Fitnesses and Allele Frequencies in a Population With Spatially Heterogeneous Selection Pressures Genetics, November 1, 2007; 177(3): 1743 - 1751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Star, R. J. Stoffels, and H. G. Spencer Single-Locus Polymorphism in a Heterogeneous Two-Deme Model Genetics, July 1, 2007; 176(3): 1625 - 1633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Burger and A. Gimelfarb The Effects of Intraspecific Competition and Stabilizing Selection on a Polygenic Trait Genetics, July 1, 2004; 167(3): 1425 - 1443. [Abstract] [Full Text] [PDF]
|
|