Female Sterile Mutations on the Second Chromosome of Drosophila melanogaster. II. Mutations Blocking Oogenesis or Altering Egg Morphology

INVESTIGATIONS

Female Sterile Mutations on the Second Chromosome of Drosophila melanogaster. II. Mutations Blocking Oogenesis or Altering Egg Morphology

T. Schupbach and E. Wieschaus
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544

In mutagenesis screens for recessive female sterile mutations on the second chromosome of Drosophila melanogaster 528 lines were isolated which allow the homozygous females to survive but cause sterility. In 62 of these lines early stages of oogenesis are affected, and these females usually do not lay any eggs. In 333 lines oogenesis proceeds apparently normally to stage 8 of oogenesis, but morphological defects become often apparent during later stages of oogenesis, and are visible in the defective eggs produced by these females whereas 133 lay eggs that appear morphologically normal, but do not support normal embryonic development. Of the lines 341 have been genetically characterized and define a total of 140 loci on the second chromosome. Not all the loci are specific for oogenesis. From the numbers obtained we estimate that the second chromosome of Drosophila contains about 13 loci that are relatively specific for early oogenesis, 70 loci that are specifically required in mid to late oogenesis, and around 30 maternal-effect lethals.

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				J. P. Blumenstiel, R. Fu, W. E. Theurkauf, and R. S. Hawley Components of the RNAi Machinery That Mediate Long-Distance Chromosomal Associations Are Dispensable for Meiotic and Early Somatic Homolog Pairing in Drosophila melanogaster Genetics, November 1, 2008; 180(3): 1355 - 1365. [Abstract] [Full Text] [PDF]

				T. Flatt, K.-J. Min, C. D'Alterio, E. Villa-Cuesta, J. Cumbers, R. Lehmann, D. L. Jones, and M. Tatar Drosophila germ-line modulation of insulin signaling and lifespan PNAS, April 29, 2008; 105(17): 6368 - 6373. [Abstract] [Full Text] [PDF]

				V. Specchia, C. Benna, G. M. Mazzotta, A. Piccin, M. A. Zordan, R. Costa, and M. P. Bozzetti aubergine Gene Overexpression in Somatic Tissues of auberginesting Mutants Interferes With the RNAi Pathway of a yellow Hairpin dsRNA in Drosophila melanogaster Genetics, March 1, 2008; 178(3): 1271 - 1282. [Abstract] [Full Text] [PDF]

				C. Klattenhoff and W. Theurkauf Biogenesis and germline functions of piRNAs Development, January 1, 2008; 135(1): 3 - 9. [Abstract] [Full Text] [PDF]

				V. Barbosa, N. Kimm, and R. Lehmann A Maternal Screen for Genes Regulating Drosophila Oocyte Polarity Uncovers New Steps in Meiotic Progression Genetics, August 1, 2007; 176(4): 1967 - 1977. [Abstract] [Full Text] [PDF]

				A. K. Lim and T. Kai Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster PNAS, April 17, 2007; 104(16): 6714 - 6719. [Abstract] [Full Text] [PDF]

				A. Pelisson, E. Sarot, G. Payen-Groschene, and A. Bucheton A Novel Repeat-Associated Small Interfering RNA-Mediated Silencing Pathway Downregulates Complementary Sense gypsy Transcripts in Somatic Cells of the Drosophila Ovary J. Virol., February 15, 2007; 81(4): 1951 - 1960. [Abstract] [Full Text] [PDF]

				V. Mirouse, E. Formstecher, and J.-L. Couderc Interaction between Polo and BicD proteins links oocyte determination and meiosis control in Drosophila Development, October 15, 2006; 133(20): 4005 - 4013. [Abstract] [Full Text] [PDF]

				R. S. Shapiro and K. V. Anderson Drosophila Ik2, a member of the I{kappa}B kinase family, is required for mRNA localization during oogenesis Development, April 15, 2006; 133(8): 1467 - 1475. [Abstract] [Full Text] [PDF]

				S. H. Cole, G. E. Carney, C. A. McClung, S. S. Willard, B. J. Taylor, and J. Hirsh Two Functional but Noncomplementing Drosophila Tyrosine Decarboxylase Genes: DISTINCT ROLES FOR NEURAL TYRAMINE AND OCTOPAMINE IN FEMALE FERTILITY J. Biol. Chem., April 15, 2005; 280(15): 14948 - 14955. [Abstract] [Full Text] [PDF]

				L. M. Ditch, T. Shirangi, J. L. Pitman, K. L. Latham, K. D. Finley, P. T. Edeen, B. J. Taylor, and M. McKeown Drosophila retained/dead ringer is necessary for neuronal pathfinding, female receptivity and repression of fruitless independent male courtship behaviors Development, January 1, 2005; 132(1): 155 - 164. [Abstract] [Full Text] [PDF]

				N. Yan and P. M. Macdonald Genetic Interactions of Drosophila melanogaster arrest Reveal Roles for Translational Repressor Bruno in Accumulation of Gurken and Activity of Delta Genetics, November 1, 2004; 168(3): 1433 - 1442. [Abstract] [Full Text] [PDF]

				S. S. Willard, E. F. Ozdowski, N. A. Jones, and C. Cronmiller stall-Mediated Extrinsic Control of Ovarian Follicle Formation in Drosophila Genetics, September 1, 2004; 168(1): 191 - 198. [Abstract] [Full Text] [PDF]

				H. Zhang and J. Tower Sequence requirements for function of the Drosophila chorion gene locus ACE3 replicator and ori-{beta} origin elements Development, May 1, 2004; 131(9): 2089 - 2099. [Abstract] [Full Text] [PDF]

				S. Luschnig, B. Moussian, J. Krauss, I. Desjeux, J. Perkovic, and C. Nusslein-Volhard An F1 Genetic Screen for Maternal-Effect Mutations Affecting Embryonic Pattern Formation in Drosophila melanogaster Genetics, May 1, 2004; 167(1): 325 - 342. [Abstract] [Full Text] [PDF]

				M. J. Snee and P. M. Macdonald Live imaging of nuage and polar granules: evidence against a precursor-product relationship and a novel role for Oskar in stabilization of polar granule components J. Cell Sci., April 15, 2004; 117(10): 2109 - 2120. [Abstract] [Full Text] [PDF]

				T. Iida and M. A. Lilly missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in Drosophila Development, March 1, 2004; 131(5): 1029 - 1039. [Abstract] [Full Text] [PDF]

				M. PAL-BHADRA, U. BHADRA, and J.A. BIRCHLER Interrelationship of RNA Interference and Transcriptional Gene Silencing in Drosophila Cold Spring Harb Symp Quant Biol, January 1, 2004; 69(0): 433 - 438. [Abstract] [PDF]

				J. E. Wilhelm, M. Hilton, Q. Amos, and W. J. Henzel Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz J. Cell Biol., December 22, 2003; 163(6): 1197 - 1204. [Abstract] [Full Text] [PDF]

				D. H. Tran and C. A. Berg bullwinkle and shark regulate dorsal-appendage morphogenesis in Drosophila oogenesis Development, December 22, 2003; 130(25): 6273 - 6282. [Abstract] [Full Text] [PDF]

				W. Zhang, Y. Jin, Y. Ji, J. Girton, J. Johansen, and K. M. Johansen Genetic and Phenotypic Analysis of Alleles of the Drosophila Chromosomal JIL-1 Kinase Reveals a Functional Requirement at Multiple Developmental Stages Genetics, November 1, 2003; 165(3): 1341 - 1354. [Abstract] [Full Text] [PDF]

				U. Abdu, A. Gonzalez-Reyes, A. Ghabrial, and T. Schupbach The Drosophila spn-D Gene Encodes a RAD51C-Like Protein That Is Required Exclusively During Meiosis Genetics, September 1, 2003; 165(1): 197 - 204. [Abstract] [Full Text] [PDF]

				S. G. Martin, V. Leclerc, K. Smith-Litiere, and D. S. Johnston The identification of novel genes required for Drosophila anteroposterior axis formation in a germline clone screen using GFP-Staufen Development, September 1, 2003; 130(17): 4201 - 4215. [Abstract] [Full Text] [PDF]

				P. Lasko Gene Regulation at the RNA Layer: RNA Binding Proteins in Intercellular Signaling Networks Sci. Signal., April 22, 2003; 2003(179): re6 - re6. [Abstract] [Full Text] [PDF]

				R. T. Cox and A. C. Spradling A Balbiani body and the fusome mediate mitochondrial inheritance during Drosophila oogenesis Development, April 15, 2003; 130(8): 1579 - 1590. [Abstract] [Full Text] [PDF]

				A. Hong, S. Lee-Kong, T. Iida, I. Sugimura, and M. A. Lilly The p27cip/kip ortholog dacapo maintains the Drosophila oocyte in prophase of meiosis I Development, April 1, 2003; 130(7): 1235 - 1242. [Abstract] [Full Text] [PDF]

				S. D. Findley, M. Tamanaha, N. J. Clegg, and H. Ruohola-Baker Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage Development, March 1, 2003; 130(5): 859 - 871. [Abstract] [Full Text] [PDF]

				J.-Y. Ji, M. Haghnia, C. Trusty, L. S. B. Goldstein, and G. Schubiger A Genetic Screen for Suppressors and Enhancers of the Drosophila Cdk1-Cyclin B Identifies Maternal Factors That Regulate Microtubule and Microfilament Stability Genetics, November 1, 2002; 162(3): 1179 - 1195. [Abstract] [Full Text] [PDF]