Lack of Polymorphism on the Drosophila Fourth Chromosome Resulting From Selection

INVESTIGATIONS

Lack of Polymorphism on the Drosophila Fourth Chromosome Resulting From Selection

A. J. Berry, J. W. Ajioka and M. Kreitman
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544

Evolutionary processes can be inferred from comparisons of intraspecific polymorphism and interspecific divergence. We sequenced a 1.1-kb fragment of the cubitus interruptus Dominant (ci(D)) locus located on the nonrecombining fourth chromosome for ten natural lines of Drosophila melanogaster and nine of Drosophila simulans. We found no polymorphism within D. melanogaster and a single polymorphism within D. simulans; divergence between the species was about 5%. Comparison with the alcohol dehydrogenase gene and its two flanking regions in D. melanogaster, for which comparable data are available, revealed a statistically significant departure from neutrality in all three tests. This lack of polymorphism in the ci(D) locus may reflect recent positive selective sweeps on the fourth chromosome with extreme hitchhiking generated by the lack of recombination. By simulation, we estimate there to be a 50% chance that the selective sweeps occurred within the past 30,000 years in D. melanogaster and 75,000 in D. simulans.

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				W. Wang, K. Thornton, J. J. Emerson, and M. Long Nucleotide Variation and Recombination Along the Fourth Chromosome in Drosophila simulans Genetics, April 1, 2004; 166(4): 1783 - 1794. [Abstract] [Full Text] [PDF]

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				W. Wang, K. Thornton, A. Berry, and M. Long Nucleotide Variation Along the Drosophila melanogaster Fourth Chromosome Science, January 4, 2002; 295(5552): 134 - 137. [Abstract] [Full Text] [PDF]

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