Genetics, Vol 129, 783-789, Copyright © 1991

INVESTIGATIONS

Embryonic Head Involution and Rotation of Male Terminalia Require the Drosophila Locus head involution defective

M. K. Abbott and J. A. Lengyel
Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 Present address: Division of Biology, Ackert Hall, Kansas State University, Manhattan, Kansas 66506.

We have characterized the head involution defective (hid) locus which is located within the chromosomal region 75B8-C1,2. During the morphogenetic reorganization of the embryonic head region, hid(+) function is necessary for the movement of the dorsal fold across the procephalon and clypeolabrum, a process that forms the frontal sac. The absence of the frontal sac in the hid mutant embryos affects the formation of the dorsal bridge and disrupts the development of the larval cephalopharyngeal skeleton. In addition to its embryonic role, this same hid function is also required during pupal development for the 360{deg} rotation of the male terminalia about the anterior-posterior body axis, and for a late step of wing blade morphogenesis. Although the abnormal wing phenotype caused by the Wrinkled (W) mutation is quite different from the one resulting from the loss-of-function hid mutations, the characterization of EMS-induced W revertants reveals that W is actually an antimorphic allele of hid.

This article has been cited by other articles:

				R. J. Krieser, F. E. Moore, D. Dresnek, B. J. Pellock, R. Patel, A. Huang, C. Brachmann, and K. White The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis Development, July 1, 2007; 134(13): 2407 - 2414. [Abstract] [Full Text] [PDF]

				A. Rogulja-Ortmann, K. Luer, J. Seibert, C. Rickert, and G. M. Technau Programmed cell death in the embryonic central nervous system of Drosophila melanogaster Development, January 1, 2007; 134(1): 105 - 116. [Abstract] [Full Text] [PDF]

				A. Singh, X. Shi, and K.-W. Choi Lobe and Serrate are required for cell survival during early eye development in Drosophila. Development, December 1, 2006; 133(23): 4771 - 4781. [Abstract] [Full Text] [PDF]

				S. Polaski, L. Whitney, B. W. Barker, and B. Stronach Genetic Analysis of Slipper/Mixed Lineage Kinase Reveals Requirements in Multiple Jun-N-Terminal Kinase-Dependent Morphogenetic Events During Drosophila Development Genetics, October 1, 2006; 174(2): 719 - 733. [Abstract] [Full Text] [PDF]

				I. Muro, D. L. Berry, J. R. Huh, C. H. Chen, H. Huang, S. J. Yoo, M. Guo, E. H. Baehrecke, and B. A. Hay The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process Development, September 1, 2006; 133(17): 3305 - 3315. [Abstract] [Full Text] [PDF]

				D. G. McEwen and M. Peifer Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis Development, September 1, 2005; 132(17): 3935 - 3946. [Abstract] [Full Text] [PDF]

				D. Xu, Y. Li, M. Arcaro, M. Lackey, and A. Bergmann The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila Development, May 1, 2005; 132(9): 2125 - 2134. [Abstract] [Full Text] [PDF]

				J. Terashima and M. Bownes Translating Available Food Into the Number of Eggs Laid by Drosophila melanogaster Genetics, August 1, 2004; 167(4): 1711 - 1719. [Abstract] [Full Text] [PDF]

				V. P. Yin and C. S. Thummel A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila PNAS, May 25, 2004; 101(21): 8022 - 8027. [Abstract] [Full Text] [PDF]

				M. R. Olson, C. L. Holley, E. C. Gan, D. A. Colon-Ramos, B. Kaplan, and S. Kornbluth A GH3-like Domain in Reaper Is Required for Mitochondrial Localization and Induction of IAP Degradation J. Biol. Chem., November 7, 2003; 278(45): 44758 - 44768. [Abstract] [Full Text] [PDF]

				G. Adam, N. Perrimon, and S. Noselli The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila Development, June 1, 2003; 130(11): 2397 - 2406. [Abstract] [Full Text] [PDF]

				C. Lee and E. Baehrecke Steroid regulation of autophagic programmed cell death during development Development, January 4, 2001; 128(8): 1443 - 1455. [Abstract] [PDF]

				R. T. Cox, D. G. McEwen, D. L. Myster, R. J. Duronio, J. Loureiro, and M. Peifer A Screen for Mutations That Suppress the Phenotype of Drosophila armadillo, the {beta}-Catenin Homolog Genetics, August 1, 2000; 155(4): 1725 - 1740. [Abstract] [Full Text]

				M. H. Brodsky, J. J. Sekelsky, G. Tsang, R. S. Hawley, and G. M. Rubin mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development Genes & Dev., March 15, 2000; 14(6): 666 - 678. [Abstract] [Full Text]

				D. A. Wassarman, N. Aoyagi, L. A. Pile, and E. M. Schlag TAF250 is required for multiple developmental events in Drosophila PNAS, February 1, 2000; 97(3): 1154 - 1159. [Abstract] [Full Text] [PDF]

				W. N. Haining, C. Carboy-Newcomb, C. L. Wei, and H. Steller The proapoptotic function of Drosophila Hid is conserved in mammalian cells PNAS, April 27, 1999; 96(9): 4936 - 4941. [Abstract] [Full Text] [PDF]

				C Jiang, E. Baehrecke, and C. Thummel Steroid regulated programmed cell death during Drosophila metamorphosis Development, January 11, 1997; 124(22): 4673 - 4683. [Abstract] [PDF]

				P Chen, W Nordstrom, B Gish, and J M Abrams grim, a novel cell death gene in Drosophila. Genes & Dev., July 15, 1996; 10(14): 1773 - 1782. [Abstract] [PDF]

				M E Grether, J M Abrams, J Agapite, K White, and H Steller The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes & Dev., July 15, 1995; 9(14): 1694 - 1708. [Abstract] [PDF]

				K White, M. Grether, J. Abrams, L Young, K Farrell, and H Steller Genetic control of programmed cell death in Drosophila Science, April 29, 1994; 264(5159): 677 - 683. [Abstract] [PDF]