- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Fieldhouse, D.
- Articles by Golding, B.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Fieldhouse, D.
- Articles by Golding, B.
Genetics, Vol 129, 563-572, Copyright © 1991
INVESTIGATIONS |
A Source of Small Repeats in Genomic DNA
D. Fieldhouse and B. Golding
Department of Biology, York University, North York, Ontario M3J 1P3, Canada
The processes of spontaneous mutation are known to be influenced by neighboring DNA. Imperfect nearby repeats in the neighboring DNA have been observed to mutate to form perfect repeats. The repeats may be either direct or inverted. Such a mutational process should create perfect direct and inverted repeats in intergenic DNA. A larger than expected number of direct repeats has generally been observed in a wide range of species in both coding and noncoding DNA. Simulations are carried out to determine how this process might influence the repetitive structure of genomic DNA. These simulations show that small repeats created by this kind of a mutational process can explain the excess number of repeats in intergenic DNA. The simulations suggest that this mechanism may be a common cause of mutations, including single-base changes. The influences of the distance between imperfect repeats and of their degree of similarity are investigated.
This article has been cited by other articles:
 |
|
 |
|
  S. J. McTaggart and T. J. Crease Selection on the Structural Stability of a Ribosomal RNA Expansion Segment in Daphnia obtusa Mol. Biol. Evol., May 1, 2005; 22(5): 1309 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. DeMarini, M. L. Shelton, A. Abu-Shakra, A. Szakmary, and J. G. Levine Spectra of Spontaneous Frameshift Mutations at the hisD3052 Allele of Salmonella typhimurium in Four DNA Repair Backgrounds Genetics, May 1, 1998; 149(1): 17 - 36. [Abstract] [Full Text] [PDF]
|
|