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Genetics, Vol 126, 823-835, Copyright © 1990
INVESTIGATIONS |
An RME1-Independent Pathway for Sporulation Control in Saccharomyces cerevisiae Acts Through IME1 Transcript Accumulation
G. Kao, J. C. Shah and M. J. Clancy
Present address: Department of Biology, Princeton University, Princeton, New Jersey 08544.
The RES1-1 mutation was isolated on the basis of its ability to allow MATa/MAT{alpha} diploid Saccharomyces cerevisiae cells to express a late sporulation-regulated gene, SPR3, in the presence of excess copies of RME1. RME1 is a repressor of meiosis that is normally expressed in cells that lack the a1/{alpha}2 repressor encoded by MAT. The RES1-1 mutation also supports sporulation in mat-insufficient diploids. This phenotype does not result from a failure to express RME1 and is not due to activation of the silent copies of mating type information. RES1-1 activates sporulation by allowing IME1 accumulation in all cell types, irrespective of the presence of the MAT products. IME1 is still responsive to RME1 in RES1-1 cells, since double mutants (rme1 RES1-1) that are deficient at MAT can sporulate better than either single mutant. RES1-1 is not an allele of IME1.
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  S. Sagee, A. Sherman, G. Shenhar, K. Robzyk, N. Ben-Doy, G. Simchen, and Y. Kassir Multiple and Distinct Activation and Repression Sequences Mediate the Regulated Transcription of IME1, a Transcriptional Activator of Meiosis-Specific Genes in Saccharomyces cerevisiae Mol. Cell. Biol., April 1, 1998; 18(4): 1985 - 1995. [Abstract] [Full Text]
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 P A Covitz, I Herskowitz, and A P Mitchell The yeast RME1 gene encodes a putative zinc finger protein that is directly repressed by a1-alpha 2. Genes & Dev., November 1, 1991; 5(11): 1982 - 1989. [Abstract] [PDF]
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