Genetics, Vol 126, 639-650, Copyright © 1990

INVESTIGATIONS

Genetics of 51D-52A, a Region Containing Several Maternal-Effect Genes and Two Maternal-Specific Transcripts in Drosophila

E. M. Underwood, A. S. Briot, K. Z. Doll, R. L. Ludwiczak, D. C. Otteson, J. Tower, K. B. Vessey and K. Yu
Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio 43403

Two genomic clones exhibiting a maternal-specific pattern of expression map to cytological region 52A. To elucidate the function of these clones we have undertaken a mutagenesis of the cytological region 51D-52A. This paper presents the results of this screen and the preliminary analysis of female-sterile and lethal mutations isolated. A total of twelve complementation groups have been identified, four of which are defined exclusively by female-sterile alleles. Only one visible mutation was isolated, a recessive temperature-sensitive allele of Thickened-arista (Ta(rts)). Several of the seven lethal loci display an embryonic lethal phase. Three of the four female-sterile loci affect chorion structure with one resulting in underamplification of the chorion genes, and two (possibly three) of the four female-steriles affect nuclear division/DNA replication. Thus it appears that this is a ``developmentally important'' region, possibly representing a clustering of genes involved in either DNA replication or nuclear division.

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