Meiosis in Asynaptic Yeast

INVESTIGATIONS

Meiosis in Asynaptic Yeast

B. Rockmill and G. S. Roeder
Department of Biology, Yale University, New Haven, Connecticut 06511-8112

The Saccharomyces cerevisiae red1 mutant fails to assemble synaptonemal complex during meiotic prophase. This mutant displays locus-specific reductions in interchromosomal gene conversion and a moderate reduction in crossing over. The occurrence of a significant amount of meiotically induced recombination in the red1 mutant indicates that the synaptonemal complex is not absolutely required for meiotic exchange. The RED1 gene product is required for intrachromosomal recombination in some assays but not others. Chromosomes that have undergone reciprocal exchange nevertheless nondisjoin in red1 mutants, indicating that crossovers are not sufficient for disjunction. Epistasis studies reveal that HOP1 is epistatic to RED1, and that RED1 acts in an independent pathway from MER1. A model for the function of the RED1 gene product in chromosome synapsis is discussed.

This article has been cited by other articles:

S. D. Sheridan, X. Yu, R. Roth, J. E. Heuser, M. G. Sehorn, P. Sung, E. H. Egelman, and D. K. Bishop
A comparative analysis of Dmc1 and Rad51 nucleoprotein filaments
Nucleic Acids Res., July 1, 2008; 36(12): 4057 - 4066.
[Abstract] [Full Text] [PDF]

F. Conde and P. A. San-Segundo
Role of Dot1 in the Response to Alkylating DNA Damage in Saccharomyces cerevisiae: Regulation of DNA Damage Tolerance by the Error-Prone Polymerases Pol{zeta}/Rev1
Genetics, July 1, 2008; 179(3): 1197 - 1210.
[Abstract] [Full Text] [PDF]

N. Mitra and G. S. Roeder
A Novel Nonnull ZIP1 Allele Triggers Meiotic Arrest With Synapsed Chromosomes in Saccharomyces cerevisiae
Genetics, June 1, 2007; 176(2): 773 - 787.
[Abstract] [Full Text] [PDF]

J. Li, S. Agarwal, and G. S. Roeder
SSP2 and OSW1, Two Sporulation-Specific Genes Involved in Spore Morphogenesis in Saccharomyces cerevisiae
Genetics, January 1, 2007; 175(1): 143 - 154.
[Abstract] [Full Text] [PDF]

B. Rockmill, K. Voelkel-Meiman, and G. S. Roeder
Centromere-Proximal Crossovers Are Associated With Precocious Separation of Sister Chromatids During Meiosis in Saccharomyces cerevisiae
Genetics, December 1, 2006; 174(4): 1745 - 1754.
[Abstract] [Full Text] [PDF]

J. L. Wells, D. W. Pryce, A. Estreicher, J. Loidl, and R. J. McFarlane
Linear Element-Independent Meiotic Recombination in Schizosaccharomyces pombe
Genetics, November 1, 2006; 174(3): 1105 - 1114.
[Abstract] [Full Text] [PDF]

M. D. Yandeau-Nelson, B. J. Nikolau, and P. S. Schnable
Effects of trans-acting Genetic Modifiers on Meiotic Recombination Across the a1-sh2 Interval of Maize
Genetics, September 1, 2006; 174(1): 101 - 112.
[Abstract] [Full Text] [PDF]

J. Li, G. W. Hooker, and G. S. Roeder
Saccharomyces cerevisiae Mer2, Mei4 and Rec114 Form a Complex Required for Meiotic Double-Strand Break Formation
Genetics, August 1, 2006; 173(4): 1969 - 1981.
[Abstract] [Full Text] [PDF]

S. Sheridan and D. K. Bishop
Red-Hed regulation: recombinase Rad51, though capable of playing the leading role, may be relegated to supporting Dmc1 in budding yeast meiosis.
Genes & Dev., July 1, 2006; 20(13): 1685 - 1691.
[Full Text] [PDF]

H. Tsubouchi and G. S. Roeder
Budding yeast Hed1 down-regulates the mitotic recombination machinery when meiotic recombination is impaired.
Genes & Dev., July 1, 2006; 20(13): 1766 - 1775.
[Abstract] [Full Text] [PDF]

D. Y. Lui, T. L. Peoples-Holst, J. Chang Mell, H.-Y. Wu, E. W. Dean, and S. M. Burgess
Analysis of Close Stable Homolog Juxtaposition During Meiosis in Mutants of Saccharomyces cerevisiae
Genetics, July 1, 2006; 173(3): 1207 - 1222.
[Abstract] [Full Text] [PDF]

C. H. Sterling and J. B. Sweasy
DNA Polymerase 4 of Saccharomyces cerevisiae Is Important for Accurate Repair of Methyl-Methanesulfonate-Induced DNA Damage
Genetics, January 1, 2006; 172(1): 89 - 98.
[Abstract] [Full Text] [PDF]

H. Niu, L. Wan, B. Baumgartner, D. Schaefer, J. Loidl, and N. M. Hollingsworth
Partner Choice during Meiosis Is Regulated by Hop1-promoted Dimerization of Mek1
Mol. Biol. Cell, December 1, 2005; 16(12): 5804 - 5818.
[Abstract] [Full Text] [PDF]

E. Trelles-Sticken, C. Adelfalk, J. Loidl, and H. Scherthan
Meiotic telomere clustering requires actin for its formation and cohesin for its resolution
J. Cell Biol., July 18, 2005; 170(2): 213 - 223.
[Abstract] [Full Text] [PDF]

D. W. Pryce, A. Lorenz, J. B. Smirnova, J. Loidl, and R. J. McFarlane
Differential Activation of M26-Containing Meiotic Recombination Hot Spots in Schizosaccharomyces pombe
Genetics, May 1, 2005; 170(1): 95 - 106.
[Abstract] [Full Text] [PDF]

S. Prieler, A. Penkner, V. Borde, and F. Klein
The control of Spo11's interaction with meiotic recombination hotspots
Genes & Dev., January 15, 2005; 19(2): 255 - 269.
[Abstract] [Full Text] [PDF]

H. Tsubouchi and G. S. Roeder
The Budding Yeast Mei5 and Sae3 Proteins Act Together With Dmc1 During Meiotic Recombination
Genetics, November 1, 2004; 168(3): 1219 - 1230.
[Abstract] [Full Text] [PDF]

K. Nabeshima, A. M. Villeneuve, and K. J. Hillers
Chromosome-Wide Regulation of Meiotic Crossover Formation in Caenorhabditis elegans Requires Properly Assembled Chromosome Axes
Genetics, November 1, 2004; 168(3): 1275 - 1292.
[Abstract] [Full Text] [PDF]

A. Lorenz, J. L. Wells, D. W. Pryce, M. Novatchkova, F. Eisenhaber, R. J. McFarlane, and J. Loidl
S. pombe meiotic linear elements contain proteins related to synaptonemal complex components
J. Cell Sci., July 1, 2004; 117(15): 3343 - 3351.
[Abstract] [Full Text] [PDF]

L. Maloisel, J. Bhargava, and G. S. Roeder
A Role for DNA Polymerase {delta} in Gene Conversion and Crossing Over During Meiosis in Saccharomyces cerevisiae
Genetics, July 1, 2004; 167(3): 1133 - 1142.
[Abstract] [Full Text] [PDF]

R. E. Malone, S. J. Haring, K. E. Foreman, M. L. Pansegrau, S. M. Smith, D. R. Houdek, L. Carpp, B. Shah, and K. E. Lee
The Signal from the Initiation of Meiotic Recombination to the First Division of Meiosis
Eukaryot. Cell, June 1, 2004; 3(3): 598 - 609.
[Abstract] [Full Text] [PDF]

L. Wan, T. de los Santos, C. Zhang, K. Shokat, and N. M. Hollingsworth
Mek1 Kinase Activity Functions Downstream of RED1 in the Regulation of Meiotic Double Strand Break Repair in Budding Yeast
Mol. Biol. Cell, January 1, 2004; 15(1): 11 - 23.
[Abstract] [Full Text] [PDF]

T. de los Santos, N. Hunter, C. Lee, B. Larkin, J. Loidl, and N. M. Hollingsworth
The Mus81/Mms4 Endonuclease Acts Independently of Double-Holliday Junction Resolution to Promote a Distinct Subset of Crossovers During Meiosis in Budding Yeast
Genetics, May 1, 2003; 164(1): 81 - 94.
[Abstract] [Full Text] [PDF]

J. S. Chang, K. Henry, B. L. Wolf, M. Geli, and S. K. Lemmon
Protein Phosphatase-1 Binding to Scd5p Is Important for Regulation of Actin Organization and Endocytosis in Yeast
J. Biol. Chem., December 6, 2002; 277(50): 48002 - 48008.
[Abstract] [Full Text] [PDF]

H. Tsubouchi and G. S. Roeder
The Mnd1 Protein Forms a Complex with Hop2 To Promote Homologous Chromosome Pairing and Meiotic Double-Strand Break Repair
Mol. Cell. Biol., May 1, 2002; 22(9): 3078 - 3088.
[Abstract] [Full Text] [PDF]

E.-J. E. Hong and G. S. Roeder
A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint
Genes & Dev., February 1, 2002; 16(3): 363 - 376.
[Abstract] [Full Text] [PDF]

T. de los Santos, J. Loidl, B. Larkin, and N. M. Hollingsworth
A Role for MMS4 in the Processing of Recombination Intermediates During Meiosis in Saccharomyces cerevisiae
Genetics, December 1, 2001; 159(4): 1511 - 1525.
[Abstract] [Full Text] [PDF]

J. Pelttari, M.-R. Hoja, L. Yuan, J.-G. Liu, E. Brundell, P. Moens, S. Santucci-Darmanin, R. Jessberger, J. L. Barbero, C. Heyting, et al.
A Meiotic Chromosomal Core Consisting of Cohesin Complex Proteins Recruits DNA Recombination Proteins and Promotes Synapsis in the Absence of an Axial Element in Mammalian Meiotic Cells
Mol. Cell. Biol., August 15, 2001; 21(16): 5667 - 5677.
[Abstract] [Full Text] [PDF]

R. Mercier, D. Vezon, E. Bullier, J. C. Motamayor, A. Sellier, F. Lefevre, G. Pelletier, and C. Horlow
SWITCH1 (SWI1): a novel protein required for the establishment of sister chromatid cohesion and for bivalent formation at meiosis
Genes & Dev., July 15, 2001; 15(14): 1859 - 1871.
[Abstract] [Full Text] [PDF]

L. Davis, M. Barbera, A. McDonnell, K. McIntyre, R. Sternglanz, Q.-w. Jin, J. Loidl, and J. Engebrecht
The Saccharomyces cerevisiae MUM2 Gene Interacts With the DNA Replication Machinery and Is Required for Meiotic Levels of Double Strand Breaks
Genetics, March 1, 2001; 157(3): 1179 - 1189.
[Abstract] [Full Text]

I. Oishi, K. Iwai, Y. Kagohashi, H. Fujimoto, K.-I. Kariya, T. Kataoka, H. Sawa, H. Okano, H. Otani, H. Yamamura, et al.
Critical Role of Caenorhabditis elegans Homologs of Cds1 (Chk2)-Related Kinases in Meiotic Recombination
Mol. Cell. Biol., February 15, 2001; 21(4): 1329 - 1335.
[Abstract] [Full Text]

P. A. San-Segundo and G. S. Roeder
Role for the Silencing Protein Dot1 in Meiotic Checkpoint Control
Mol. Biol. Cell, October 1, 2000; 11(10): 3601 - 3615.
[Abstract] [Full Text]

M. Shinohara, S. L. Gasior, D. K. Bishop, and A. Shinohara
Tid1/Rdh54 promotes colocalization of Rad51 and Dmc1 during meiotic recombination
PNAS, September 26, 2000; 97(20): 10814 - 10819.
[Abstract] [Full Text] [PDF]

D. Woltering, B. Baumgartner, S. Bagchi, B. Larkin, J. Loidl, T. de los Santos, and N. M. Hollingsworth
Meiotic Segregation, Synapsis, and Recombination Checkpoint Functions Require Physical Interaction between the Chromosomal Proteins Red1p and Hop1p
Mol. Cell. Biol., September 15, 2000; 20(18): 6646 - 6658.
[Abstract] [Full Text]

A. Miyajima, M. Seki, F. Onoda, M. Shiratori, N. Odagiri, K. Ohta, Y. Kikuchi, Y. Ohno, and T. Enomoto
Sgs1 Helicase Activity Is Required for Mitotic but Apparently Not for Meiotic Functions
Mol. Cell. Biol., September 1, 2000; 20(17): 6399 - 6409.
[Abstract] [Full Text]

L. H. Rutkowski and R. E. Esposito
Recombination Can Partially Substitute for SPO13 in Regulating Meiosis I in Budding Yeast
Genetics, August 1, 2000; 155(4): 1607 - 1621.
[Abstract] [Full Text]

J. M. Bailis, A. V. Smith, and G. S. Roeder
Bypass of a Meiotic Checkpoint by Overproduction of Meiotic Chromosomal Proteins
Mol. Cell. Biol., July 1, 2000; 20(13): 4838 - 4848.
[Abstract] [Full Text]

A. Bloecher and K. Tatchell
Dynamic Localization of Protein Phosphatase Type 1 in the Mitotic Cell Cycle of Saccharomyces cerevisiae
J. Cell Biol., April 3, 2000; 149(1): 125 - 140.
[Abstract] [Full Text] [PDF]

K. Muniyappa, S. Anuradha, and B. Byers
Yeast Meiosis-Specific Protein Hop1 Binds to G4 DNA and Promotes Its Formation
Mol. Cell. Biol., February 15, 2000; 20(4): 1361 - 1369.
[Abstract] [Full Text]

H. Dong and G. S. Roeder
Organization of the Yeast Zip1 Protein within the Central Region of the Synaptonemal Complex
J. Cell Biol., February 7, 2000; 148(3): 417 - 426.
[Abstract] [Full Text] [PDF]

J.-Y. Leu and G. S. Roeder
Splicing of the Meiosis-Specific HOP2 Transcript Utilizes a Unique 5' Splice Site
Mol. Cell. Biol., December 1, 1999; 19(12): 7933 - 7943.
[Abstract] [Full Text] [PDF]

M. Tarsounas, T. Morita, R. E. Pearlman, and P. B. Moens
RAD51 and DMC1 Form Mixed Complexes Associated with Mouse Meiotic Chromosome Cores and Synaptonemal Complexes
J. Cell Biol., October 18, 1999; 147(2): 207 - 220.
[Abstract] [Full Text] [PDF]

J. M. Grushcow, T. M. Holzen, K. J. Park, T. Weinert, M. Lichten, and D. K. Bishop
Saccharomyces cerevisiae Checkpoint Genes MEC1, RAD17 and RAD24 Are Required for Normal Meiotic Recombination Partner Choice
Genetics, October 1, 1999; 153(2): 607 - 620.
[Abstract] [Full Text] [PDF]

D. A. Thompson and F. W. Stahl
Genetic Control of Recombination Partner Preference in Yeast Meiosis: Isolation and Characterization of Mutants Elevated for Meiotic Unequal Sister-Chromatid Recombination
Genetics, October 1, 1999; 153(2): 621 - 641.
[Abstract] [Full Text] [PDF]

M. C. Zetka, I. Kawasaki, S. Strome, and F. Müller
Synapsis and chiasma formation in Caenorhabditis elegans require HIM-3, a meiotic chromosome core component that functions in chromosome segregation
Genes & Dev., September 1, 1999; 13(17): 2258 - 2270.
[Abstract] [Full Text]

L. Salem, N. Walter, and R. Malone
Suppressor Analysis of the Saccharomyces cerevisiae Gene REC104 Reveals a Genetic Interaction With REC102
Genetics, April 1, 1999; 151(4): 1261 - 1272.
[Abstract] [Full Text]

T. de los Santos and N. M. Hollingsworth
Red1p, a MEK1-dependent Phosphoprotein That Physically Interacts with Hop1p during Meiosis in Yeast
J. Biol. Chem., January 15, 1999; 274(3): 1783 - 1790.
[Abstract] [Full Text] [PDF]

J. M. Bailis and G. S. Roeder
Synaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein
Genes & Dev., November 15, 1998; 12(22): 3551 - 3563.
[Abstract] [Full Text]

B. Rockmill and G. S. Roeder
Telomere-mediated chromosome pairing during meiosis in budding yeast
Genes & Dev., August 15, 1998; 12(16): 2574 - 2586.
[Abstract] [Full Text]

K.-S. Tung and G. S. Roeder
Meiotic Chromosome Morphology and Behavior in zip1 Mutants of Saccharomyces cerevisiae
Genetics, June 1, 1998; 149(2): 817 - 832.
[Abstract] [Full Text] [PDF]

K. S. McKim, B. L. Green-Marroquin, J. J. Sekelsky, G. Chin, C. Steinberg, R. Khodosh, and R. S. Hawley
Meiotic Synapsis in the Absence of Recombination
Science, February 6, 1998; 279(5352): 876 - 878.
[Abstract] [Full Text]

J. Engebrecht, S. Masse, L. Davis, K. Rose, and T. Kessel
Yeast Meiotic Mutants Proficient for the Induction of Ectopic Recombination
Genetics, February 1, 1998; 148(2): 581 - 598.
[Abstract] [Full Text] [PDF]

C. A. Bascom-Slack and D. S. Dawson
The Yeast Motor Protein, Kar3p, Is Essential for Meiosis I
J. Cell Biol., October 20, 1997; 139(2): 459 - 467.
[Abstract] [Full Text] [PDF]

G. S. Roeder
Meiotic chromosomes: it takes two to tango
Genes & Dev., October 15, 1997; 11(20): 2600 - 2621.
[Full Text] [PDF]

A. V. Smith and G. S. Roeder
The Yeast Red1 Protein Localizes to the Cores of Meiotic Chromosomes
J. Cell Biol., March 10, 1997; 136(5): 957 - 967.
[Abstract] [Full Text] [PDF]

L Xu, B M Weiner, and N Kleckner
Meiotic cells monitor the status of the interhomolog recombination complex.
Genes & Dev., January 1, 1997; 11(1): 106 - 118.
[Abstract] [PDF]

B Rockmill, M Sym, H Scherthan, and G S Roeder
Roles for two RecA homologs in promoting meiotic chromosome synapsis.
Genes & Dev., November 1, 1995; 9(21): 2684 - 2695.
[Abstract] [PDF]

N M Hollingsworth, L Ponte, and C Halsey
MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair.
Genes & Dev., July 15, 1995; 9(14): 1728 - 1739.
[Abstract] [PDF]

B Rockmill and G S Roeder
A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination.
Genes & Dev., December 1, 1991; 5(12b): 2392 - 2404.
[Abstract] [PDF]

D. van Heemst, E. Kafer, T. John, C. Heyting, M. van Aalderen, and D. Zickler
BimD/SPO76 is at the interface of cell cycle progression, chromosome morphogenesis, and recombination
PNAS, May 22, 2001; 98(11): 6267 - 6272.
[Abstract] [Full Text] [PDF]

				F. Conde and P. A. San-Segundo Role of Dot1 in the Response to Alkylating DNA Damage in Saccharomyces cerevisiae: Regulation of DNA Damage Tolerance by the Error-Prone Polymerases Pol{zeta}/Rev1 Genetics, July 1, 2008; 179(3): 1197 - 1210. [Abstract] [Full Text] [PDF]

				N. Mitra and G. S. Roeder A Novel Nonnull ZIP1 Allele Triggers Meiotic Arrest With Synapsed Chromosomes in Saccharomyces cerevisiae Genetics, June 1, 2007; 176(2): 773 - 787. [Abstract] [Full Text] [PDF]

				J. Li, S. Agarwal, and G. S. Roeder SSP2 and OSW1, Two Sporulation-Specific Genes Involved in Spore Morphogenesis in Saccharomyces cerevisiae Genetics, January 1, 2007; 175(1): 143 - 154. [Abstract] [Full Text] [PDF]

				B. Rockmill, K. Voelkel-Meiman, and G. S. Roeder Centromere-Proximal Crossovers Are Associated With Precocious Separation of Sister Chromatids During Meiosis in Saccharomyces cerevisiae Genetics, December 1, 2006; 174(4): 1745 - 1754. [Abstract] [Full Text] [PDF]

				J. L. Wells, D. W. Pryce, A. Estreicher, J. Loidl, and R. J. McFarlane Linear Element-Independent Meiotic Recombination in Schizosaccharomyces pombe Genetics, November 1, 2006; 174(3): 1105 - 1114. [Abstract] [Full Text] [PDF]

				M. D. Yandeau-Nelson, B. J. Nikolau, and P. S. Schnable Effects of trans-acting Genetic Modifiers on Meiotic Recombination Across the a1-sh2 Interval of Maize Genetics, September 1, 2006; 174(1): 101 - 112. [Abstract] [Full Text] [PDF]

				J. Li, G. W. Hooker, and G. S. Roeder Saccharomyces cerevisiae Mer2, Mei4 and Rec114 Form a Complex Required for Meiotic Double-Strand Break Formation Genetics, August 1, 2006; 173(4): 1969 - 1981. [Abstract] [Full Text] [PDF]

				S. Sheridan and D. K. Bishop Red-Hed regulation: recombinase Rad51, though capable of playing the leading role, may be relegated to supporting Dmc1 in budding yeast meiosis. Genes & Dev., July 1, 2006; 20(13): 1685 - 1691. [Full Text] [PDF]

				H. Tsubouchi and G. S. Roeder Budding yeast Hed1 down-regulates the mitotic recombination machinery when meiotic recombination is impaired. Genes & Dev., July 1, 2006; 20(13): 1766 - 1775. [Abstract] [Full Text] [PDF]

				D. Y. Lui, T. L. Peoples-Holst, J. Chang Mell, H.-Y. Wu, E. W. Dean, and S. M. Burgess Analysis of Close Stable Homolog Juxtaposition During Meiosis in Mutants of Saccharomyces cerevisiae Genetics, July 1, 2006; 173(3): 1207 - 1222. [Abstract] [Full Text] [PDF]

				C. H. Sterling and J. B. Sweasy DNA Polymerase 4 of Saccharomyces cerevisiae Is Important for Accurate Repair of Methyl-Methanesulfonate-Induced DNA Damage Genetics, January 1, 2006; 172(1): 89 - 98. [Abstract] [Full Text] [PDF]

				H. Niu, L. Wan, B. Baumgartner, D. Schaefer, J. Loidl, and N. M. Hollingsworth Partner Choice during Meiosis Is Regulated by Hop1-promoted Dimerization of Mek1 Mol. Biol. Cell, December 1, 2005; 16(12): 5804 - 5818. [Abstract] [Full Text] [PDF]

				E. Trelles-Sticken, C. Adelfalk, J. Loidl, and H. Scherthan Meiotic telomere clustering requires actin for its formation and cohesin for its resolution J. Cell Biol., July 18, 2005; 170(2): 213 - 223. [Abstract] [Full Text] [PDF]

				D. W. Pryce, A. Lorenz, J. B. Smirnova, J. Loidl, and R. J. McFarlane Differential Activation of M26-Containing Meiotic Recombination Hot Spots in Schizosaccharomyces pombe Genetics, May 1, 2005; 170(1): 95 - 106. [Abstract] [Full Text] [PDF]

				S. Prieler, A. Penkner, V. Borde, and F. Klein The control of Spo11's interaction with meiotic recombination hotspots Genes & Dev., January 15, 2005; 19(2): 255 - 269. [Abstract] [Full Text] [PDF]

				H. Tsubouchi and G. S. Roeder The Budding Yeast Mei5 and Sae3 Proteins Act Together With Dmc1 During Meiotic Recombination Genetics, November 1, 2004; 168(3): 1219 - 1230. [Abstract] [Full Text] [PDF]

				K. Nabeshima, A. M. Villeneuve, and K. J. Hillers Chromosome-Wide Regulation of Meiotic Crossover Formation in Caenorhabditis elegans Requires Properly Assembled Chromosome Axes Genetics, November 1, 2004; 168(3): 1275 - 1292. [Abstract] [Full Text] [PDF]

				A. Lorenz, J. L. Wells, D. W. Pryce, M. Novatchkova, F. Eisenhaber, R. J. McFarlane, and J. Loidl S. pombe meiotic linear elements contain proteins related to synaptonemal complex components J. Cell Sci., July 1, 2004; 117(15): 3343 - 3351. [Abstract] [Full Text] [PDF]

				L. Maloisel, J. Bhargava, and G. S. Roeder A Role for DNA Polymerase {delta} in Gene Conversion and Crossing Over During Meiosis in Saccharomyces cerevisiae Genetics, July 1, 2004; 167(3): 1133 - 1142. [Abstract] [Full Text] [PDF]

				R. E. Malone, S. J. Haring, K. E. Foreman, M. L. Pansegrau, S. M. Smith, D. R. Houdek, L. Carpp, B. Shah, and K. E. Lee The Signal from the Initiation of Meiotic Recombination to the First Division of Meiosis Eukaryot. Cell, June 1, 2004; 3(3): 598 - 609. [Abstract] [Full Text] [PDF]

				L. Wan, T. de los Santos, C. Zhang, K. Shokat, and N. M. Hollingsworth Mek1 Kinase Activity Functions Downstream of RED1 in the Regulation of Meiotic Double Strand Break Repair in Budding Yeast Mol. Biol. Cell, January 1, 2004; 15(1): 11 - 23. [Abstract] [Full Text] [PDF]

				T. de los Santos, N. Hunter, C. Lee, B. Larkin, J. Loidl, and N. M. Hollingsworth The Mus81/Mms4 Endonuclease Acts Independently of Double-Holliday Junction Resolution to Promote a Distinct Subset of Crossovers During Meiosis in Budding Yeast Genetics, May 1, 2003; 164(1): 81 - 94. [Abstract] [Full Text] [PDF]

				J. S. Chang, K. Henry, B. L. Wolf, M. Geli, and S. K. Lemmon Protein Phosphatase-1 Binding to Scd5p Is Important for Regulation of Actin Organization and Endocytosis in Yeast J. Biol. Chem., December 6, 2002; 277(50): 48002 - 48008. [Abstract] [Full Text] [PDF]

				H. Tsubouchi and G. S. Roeder The Mnd1 Protein Forms a Complex with Hop2 To Promote Homologous Chromosome Pairing and Meiotic Double-Strand Break Repair Mol. Cell. Biol., May 1, 2002; 22(9): 3078 - 3088. [Abstract] [Full Text] [PDF]

				E.-J. E. Hong and G. S. Roeder A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint Genes & Dev., February 1, 2002; 16(3): 363 - 376. [Abstract] [Full Text] [PDF]

				T. de los Santos, J. Loidl, B. Larkin, and N. M. Hollingsworth A Role for MMS4 in the Processing of Recombination Intermediates During Meiosis in Saccharomyces cerevisiae Genetics, December 1, 2001; 159(4): 1511 - 1525. [Abstract] [Full Text] [PDF]

				J. Pelttari, M.-R. Hoja, L. Yuan, J.-G. Liu, E. Brundell, P. Moens, S. Santucci-Darmanin, R. Jessberger, J. L. Barbero, C. Heyting, et al. A Meiotic Chromosomal Core Consisting of Cohesin Complex Proteins Recruits DNA Recombination Proteins and Promotes Synapsis in the Absence of an Axial Element in Mammalian Meiotic Cells Mol. Cell. Biol., August 15, 2001; 21(16): 5667 - 5677. [Abstract] [Full Text] [PDF]

				R. Mercier, D. Vezon, E. Bullier, J. C. Motamayor, A. Sellier, F. Lefevre, G. Pelletier, and C. Horlow SWITCH1 (SWI1): a novel protein required for the establishment of sister chromatid cohesion and for bivalent formation at meiosis Genes & Dev., July 15, 2001; 15(14): 1859 - 1871. [Abstract] [Full Text] [PDF]

				L. Davis, M. Barbera, A. McDonnell, K. McIntyre, R. Sternglanz, Q.-w. Jin, J. Loidl, and J. Engebrecht The Saccharomyces cerevisiae MUM2 Gene Interacts With the DNA Replication Machinery and Is Required for Meiotic Levels of Double Strand Breaks Genetics, March 1, 2001; 157(3): 1179 - 1189. [Abstract] [Full Text]

				I. Oishi, K. Iwai, Y. Kagohashi, H. Fujimoto, K.-I. Kariya, T. Kataoka, H. Sawa, H. Okano, H. Otani, H. Yamamura, et al. Critical Role of Caenorhabditis elegans Homologs of Cds1 (Chk2)-Related Kinases in Meiotic Recombination Mol. Cell. Biol., February 15, 2001; 21(4): 1329 - 1335. [Abstract] [Full Text]