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Genetics, Vol 125, 873-879, Copyright © 1990
INVESTIGATIONS |
A Simple Method for Estimating Average Number of Nucleotide Substitutions Within and Between Populations From Restriction Data
M. Nei and J. C. Miller
Center for Demographic and Population Genetics, The University of Texas Health Science Center, Houston, Texas 77225
A simple method is proposed for estimating the average number of nucleotide substitutions per site within and between populations for the case where a large number of individuals are examined for many restriction enzymes. This method gives essentially the same results as those obtained by Nei and Li's method but saves a large amount of computer time. The variances of the quantities estimated can be obtained by the jackknife method, and these variances are very similar to those obtained by Nei and Jin's more sophisticated method. A similar simple method can also be applied to DNA sequence data.
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