Mixed Segregation of Chromosomes During Single-Division Meiosis of Saccharomyces cerevisiae

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Mixed Segregation of Chromosomes During Single-Division Meiosis of Saccharomyces cerevisiae

G. Sharon and G. Simchen
Present address: Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

Normal meiosis consists of two consecutive cell divisions in which all the chromosomes behave in a concerted manner. Yeast cells homozygous for the mutation cdc5, however, may be directed through a single meiotic division of a novel type. Dyad analysis of a cdc5/cdc5 strain with centromere-linked markers on four different chromosomes has shown that, in these meioses, some chromosomes within a given cell segregate reductionally whereas others segregate equationally. The choice between the two types of segregation in these meioses is made individually by each chromosome pair. Different chromosome pairs exhibit different segregation tendencies. Similar results were obtained for cells homozygous for cdc14.

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