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Genetics, Vol 125, 41-50, Copyright © 1990
INVESTIGATIONS |
Interactions of vestigial and scabrous With the Notch Locus of Drosophila melanogaster
L. Rabinow and J. A. Birchler
The Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
Interactions are described between the Notch locus of Drosophila melanogaster, and two other loci, scabrous and vestigial, which respectively affect the eyes and wings. The Notch locus is responsible for mediating decisions of cell fate throughout development in many different tissues. Mutations and duplications of vestigial and scabrous alter the severity of phenotypes associated with Notch mutations and duplications in a manner that is essentially tissue- and allele-specific. These interactions indicate that the products of vestigial and scabrous act in conjunction with Notch to stimulate the differentiation of specific cell types.
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