- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Yuan, L. W.
- Articles by Keil, R. L.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Yuan, L. W.
- Articles by Keil, R. L.
Genetics, Vol 124, 263-273, Copyright © 1990
INVESTIGATIONS |
Distance-Independence of Mitotic Intrachromosomal Recombination in Saccharomyces cerevisiae
L. W. Yuan and R. L. Keil
Department of Biological Chemistry, The Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033
Many genetic studies have shown that the frequency of homologous recombination depends largely on the distance in which recombination can occur. We have studied the effect of varying the length of duplicated sequences on the frequency of mitotic intrachromosomal recombination in Saccharomyces cerevisiae. We find that the frequency of recombination resulting in the loss of one of the repeats and the intervening sequences reaches a plateau when the repeats are short. In addition, the frequency of recombination to correct a point mutation contained in one of these repeats is not proportional to the size of the duplication but rather depends dramatically on the location of the mutation within the repeated sequences. However, the frequency of mitotic interchromosomal reciprocal recombination is dependent on the distance separating the markers. The difference in the response of intrachromosomal and interchromosomal mitotic recombination to increasing lengths of homology may indicate there are different rate-limiting steps for recombination in these two cases. These findings have important implications for the maintenance and evolution of duplicated sequences.
This article has been cited by other articles:
 |
|
 |
|
  C. Hornsby, K. M. Page, and I. Tomlinson The in Vivo Rate of Somatic Adenomatous Polyposis Coli Mutation Am. J. Pathol., April 1, 2008; 172(4): 1062 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Phadnis, R. A. Sia, and E. A. Sia Analysis of Repeat-Mediated Deletions in the Mitochondrial Genome of Saccharomyces cerevisiae Genetics, December 1, 2005; 171(4): 1549 - 1559. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Frank Age-specific incidence of inherited versus sporadic cancers: A test of the multistage theory of carcinogenesis PNAS, January 25, 2005; 102(4): 1071 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hiraoka, K.-i. Watanabe, K. Umezu, and H. Maki Spontaneous Loss of Heterozygosity in Diploid Saccharomyces cerevisiae Cells Genetics, December 1, 2000; 156(4): 1531 - 1548. [Abstract] [Full Text]
|
|
|
|
|
|
A. R. D. Ganley and B. Scott Extraordinary Ribosomal Spacer Length Heterogeneity in a Neotyphodium Endophyte Hybrid: Implications for Concerted Evolution Genetics, December 1, 1998; 150(4): 1625 - 1637. [Abstract] [Full Text]
|
|
|
|
|
|
A. Galli and R. H. Schiestl Effects of DNA Double-Strand and Single-Strand Breaks on Intrachromosomal Recombination Events in Cell-Cycle-Arrested Yeast Cells Genetics, July 1, 1998; 149(3): 1235 - 1250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Datta, M. Hendrix, M. Lipsitch, and S. Jinks-Robertson Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast PNAS, September 2, 1997; 94(18): 9757 - 9762. [Abstract] [Full Text] [PDF]
|
|