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Genetics, Vol 124, 157-163, Copyright © 1990
INVESTIGATIONS |
Length Heteroplasmy of Sturgeon Mitochondrial DNA: An Illegitimate Elongation Model
N. E. Buroker, J. R. Brown, T. A. Gilbert, P. J. O'Hara, A. T. Beckenbach, W. K. Thomas and M. J. Smith
School of Medicine, Department of Pediatrics, University of Washington, Seattle, Washington 98195
Extensive length polymorphism and heteroplasmy (multiple forms within an individual) of the D-loop region are observed in mitochondrial DNA of the white sturgeon (Acipenser transmontanus). The nucleotide sequence of this region, for both a short and a long form, shows that the differences are due to variable numbers of a perfect 82-bp direct repeat. We propose a model for the replicative origin of length differences, involving a competitive equilibrium between the heavy strand and the D-loop strand. This model suggests that frequent misalignment in the repeat region prior to elongation, facilitated by a stable secondary structure in the displaced strand, can explain both the polymorphism and heteroplasmy in this species.
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