Genetics, Vol 123, 585-595, Copyright © 1989

INVESTIGATIONS

Statistical Method for Testing the Neutral Mutation Hypothesis by DNA Polymorphism

F. Tajima
Department of Biology, Kyushu University, Fukuoka 812, Japan

The relationship between the two estimates of genetic variation at the DNA level, namely the number of segregating sites and the average number of nucleotide differences estimated from pairwise comparison, is investigated. It is found that the correlation between these two estimates is large when the sample size is small, and decreases slowly as the sample size increases. Using the relationship obtained, a statistical method for testing the neutral mutation hypothesis is developed. This method needs only the data of DNA polymorphism, namely the genetic variation within population at the DNA level. A simple method of computer simulation, that was used in order to obtain the distribution of a new statistic developed, is also presented. Applying this statistical method to the five regions of DNA sequences in Drosophila melanogaster, it is found that large insertion/deletion (>100 bp) is deleterious. It is suggested that the natural selection against large insertion/deletion is so weak that a large amount of variation is maintained in a population.


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 MycologiaHome page
M. Andrew, T.L. Peever, and B.M. Pryor
An expanded multilocus phylogeny does not resolve morphological species within the small-spored Altemrnaria species complex.
Mycologia, January 1, 2009; 101(1): 95 - 109.
[Abstract] [Full Text] [PDF]

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 J HeredHome page
H. Chen, P. L. Morrell, V. E. T. M. Ashworth, M. de la Cruz, and M. T. Clegg
Tracing the Geographic Origins of Major Avocado Cultivars
J. Hered., January 1, 2009; 100(1): 56 - 65.
[Abstract] [Full Text] [PDF]

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 J HeredHome page
R. M. Jennings, T. M. Shank, L. S. Mullineaux, and K. M. Halanych
Assessment of the Cape Cod Phylogeographic Break Using the Bamboo Worm Clymenella torquata Reveals the Role of Regional Water Masses in Dispersal
J. Hered., January 1, 2009; 100(1): 86 - 96.
[Abstract] [Full Text] [PDF]

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 J HeredHome page
K. H. Takahashi, K. Tanaka, M. Itoh, and T. Takano-Shimizu
Reduced X-Linked Rare Polymorphism in Males in Comparison to Females of Drosophila melanogaster
J. Hered., January 1, 2009; 100(1): 97 - 105.
[Abstract] [Full Text] [PDF]

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 J HeredHome page
S. E. Alter, S. F. Ramirez, S. Nigenda, J. U. Ramirez, L. R. Bracho, and S. R. Palumbi
Mitochondrial and Nuclear Genetic Variation across Calving Lagoons in Eastern North Pacific Gray Whales (Eschrichtius robustus)
J. Hered., January 1, 2009; 100(1): 34 - 46.
[Abstract] [Full Text] [PDF]

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 GeneticsHome page
J. A. Anderson, W. D. Gilliland, and C. H. Langley
Molecular Population Genetics and Evolution of Drosophila Meiosis Genes
Genetics, January 1, 2009; 181(1): 177 - 185.
[Abstract] [Full Text] [PDF]

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 GeneticsHome page
J. Wakeley and O. Sargsyan
Extensions of the Coalescent Effective Population Size
Genetics, January 1, 2009; 181(1): 341 - 345.
[Abstract] [Full Text] [PDF]

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 Mol Biol EvolHome page
M. Aguade
Nucleotide and Copy-Number Polymorphism at the Odorant Receptor Genes Or22a and Or22b in Drosophila melanogaster
Mol. Biol. Evol., January 1, 2009; 26(1): 61 - 70.
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 Mol Biol EvolHome page
A. N. Lau, L. Peng, H. Goto, L. Chemnick, O. A. Ryder, and K. D. Makova
Horse Domestication and Conservation Genetics of Przewalski's Horse Inferred from Sex Chromosomal and Autosomal Sequences
Mol. Biol. Evol., January 1, 2009; 26(1): 199 - 208.
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 J. Clin. Endocrinol. Metab.Home page
K. Rull, L. Nagirnaja, V.-M. Ulander, P. Kelgo, T. Margus, M. Kaare, K. Aittomaki, and M. Laan
Chorionic Gonadotropin {beta}-Gene Variants Are Associated with Recurrent Miscarriage in Two European Populations
J. Clin. Endocrinol. Metab., December 1, 2008; 93(12): 4697 - 4706.
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 Mol Biol EvolHome page
A. E. Palme, M. Wright, and O. Savolainen
Patterns of Divergence among Conifer ESTs and Polymorphism in Pinus sylvestris Identify Putative Selective Sweeps
Mol. Biol. Evol., December 1, 2008; 25(12): 2567 - 2577.
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 Mol Biol EvolHome page
J. A. Tennessen and M. S. Blouin
Balancing Selection at a Frog Antimicrobial Peptide Locus: Fluctuating Immune Effector Alleles?
Mol. Biol. Evol., December 1, 2008; 25(12): 2669 - 2680.
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 Mol Biol EvolHome page
B. C. Verrelli, C. M. Lewis Jr, A. C. Stone, and G. H. Perry
Different Selective Pressures Shape the Molecular Evolution of Color Vision in Chimpanzee and Human Populations
Mol. Biol. Evol., December 1, 2008; 25(12): 2735 - 2743.
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 Mol Biol EvolHome page
F. Pereira, P. Soares, J. Carneiro, L. Pereira, M. B. Richards, D. C. Samuels, and A. Amorim
Evidence for Variable Selective Pressures at a Large Secondary Structure of the Human Mitochondrial DNA Control Region
Mol. Biol. Evol., December 1, 2008; 25(12): 2759 - 2770.
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 Appl. Environ. Microbiol.Home page
P. Vinuesa, K. Rojas-Jimenez, B. Contreras-Moreira, S. K. Mahna, B. N. Prasad, H. Moe, S. B. Selvaraju, H. Thierfelder, and D. Werner
Multilocus Sequence Analysis for Assessment of the Biogeography and Evolutionary Genetics of Four Bradyrhizobium Species That Nodulate Soybeans on the Asiatic Continent
Appl. Envir. Microbiol., November 15, 2008; 74(22): 6987 - 6996.
[Abstract] [Full Text] [PDF]