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Genetics, Vol 123, 585-595, Copyright © 1989
INVESTIGATIONS |
Statistical Method for Testing the Neutral Mutation Hypothesis by DNA Polymorphism
F. Tajima
Department of Biology, Kyushu University, Fukuoka 812, Japan
The relationship between the two estimates of genetic variation at the DNA level, namely the number of segregating sites and the average number of nucleotide differences estimated from pairwise comparison, is investigated. It is found that the correlation between these two estimates is large when the sample size is small, and decreases slowly as the sample size increases. Using the relationship obtained, a statistical method for testing the neutral mutation hypothesis is developed. This method needs only the data of DNA polymorphism, namely the genetic variation within population at the DNA level. A simple method of computer simulation, that was used in order to obtain the distribution of a new statistic developed, is also presented. Applying this statistical method to the five regions of DNA sequences in Drosophila melanogaster, it is found that large insertion/deletion (>100 bp) is deleterious. It is suggested that the natural selection against large insertion/deletion is so weak that a large amount of variation is maintained in a population.
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P. R. Haddrill, D. Bachtrog, and P. Andolfatto Positive and Negative Selection on Noncoding DNA in Drosophila simulans Mol. Biol. Evol., September 1, 2008; 25(9): 1825 - 1834. [Abstract] [Full Text] [PDF] |
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S. J. Irausquin and A. L. Hughes Distinctive pattern of sequence polymorphism in the NS3 protein of hepatitis C virus type 1b reflects conflicting evolutionary pressures J. Gen. Virol., August 1, 2008; 89(8): 1921 - 1929. [Abstract] [Full Text] [PDF] |
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J. D. Wall, M. P. Cox, F. L. Mendez, A. Woerner, T. Severson, and M. F. Hammer A novel DNA sequence database for analyzing human demographic history Genome Res., August 1, 2008; 18(8): 1354 - 1361. [Abstract] [Full Text] [PDF] |
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C. Nobrega, M. Khadem, M. Aguade, and C. Segarra Genetic Exchange versus Genetic Differentiation in a Medium-Sized Inversion of Drosophila: The A2/Ast Arrangements of Drosophila subobscura Mol. Biol. Evol., August 1, 2008; 25(8): 1534 - 1543. [Abstract] [Full Text] [PDF] |
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W. Ferguson, S. Dvora, J. Gallo, A. Orth, and S. Boissinot Long-Term Balancing Selection at the West Nile Virus Resistance Gene, Oas1b, Maintains Transspecific Polymorphisms in the House Mouse Mol. Biol. Evol., August 1, 2008; 25(8): 1609 - 1618. [Abstract] [Full Text] [PDF] |
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