Genetics, Vol 123, 217-227, Copyright © 1989

INVESTIGATIONS

Genotypic Variation for a Quantitative Character Maintained Under Stabilizing Selection Without Mutations: Epistasis

A. Gimelfarb
Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois 60637

A model of the gene action on a quantitative character is suggested. The model takes into account epistasis by combining multiplicative with the traditional additive approximation of the action of loci. It is demonstrated on the basis of this model that a high level of genotypic variation can be maintained in a population for a quantitative character under stabilizing selection in the absence of mutations, if there is epistasis. It is also shown that a large amount of additive variation as well as high heritability can be ``hidden'' in such a population and ``released'' if stabilizing selection is relaxed.

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