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Genetics, Vol 123, 173-179, Copyright © 1989
INVESTIGATIONS |
Normal Testis Determination in the Mouse Depends on Genetic Interaction of a Locus on Chromosome 17 and the Y Chromosome
L. L. Washburn and E. M. Eicher
The Jackson Laboratory, Bar Harbor, Maine 04609
We previously described a locus on chromosome (Chr) 17 of the mouse that is critical for normal testis development. This locus was designated ``T-associated sex reversal'' (Tas) because it segregated with the dominant brachyury allele hairpin tail (T(hp)) and caused gonads of C57BL/6J XY, T(hp)/+ individuals to develop as ovaries or ovotestes rather than as testes. To clarify the inheritance of Tas, we investigated the effects of T-Orleans (T(Orl)), another brachyury mutation, on gonad development. We found that gonads of C57BL/6J XY, T(hp)/+ and T(Orl)/+ mice develop ovarian tissue if the Y chromosome is derived from the AKR/J inbred strain, whereas normal testicular development occurs in the presence of a Y chromosome derived from the C57BL/6J inbred strain. From these observations we conclude that: (1) Tas is located in a region on Chr 17 common to the deletions associated with T(hp), and T(Orl), and (2) the Y-linked testis determining gene, Tdy, carried by the AKR/J inbred strain differs from that of the C57BL/6J inbred strain. We suggest that in mammals Tdy is not the sole testis determinant because autosomal loci must be genetically compatible with Tdy for normal testicular development.
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