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Genetics, Vol 121, 803-809, Copyright © 1989
INVESTIGATIONS |
Localization of Murine X and Autosomal Sequences Homologous to the Human Y Located Testis-Determining Region
M. Mitchell, D. Simon, N. Affara, M. Ferguson-Smith, P. Avner and C. Bishop
Unite d'Immunogenetique Humaine, 75724 Paris Cedex 15, France
Recently a candidate gene for the primary testis-determining factor (TDF) encoding a zinc finger protein (ZFY) has been cloned from the human Y chromosome. A highly homologous X-linked copy has also been identified. Using this human sequence it is possible to identify two Y loci, an X and an autosomal locus in the mouse (Zfy-1, Zfy-2, Zfx and Zfa, respectively). Surprisingly ZFY is more homologous to the mouse X and autosomal sequences than it is to either of the Y-linked loci. Both Zfy-1 and Zfy-2 are present in the Sxr region of the Y but Zfy-2 is absent in the Sxr deletion variant Sxr(b) (or Sxr") suggesting it is not necessary for male determination. Extensive backcross analyses map Zfa to mouse chromosome 10 and Zfx to a 5-cM interval between anonymous X probe MDXS120 and the tabby locus (Ta). We also show that the mouse androgen receptor locus (m-AR) believed to underlie the testicular feminization mutation (Tfm) shows complete linkage to Zfx. Comparative mapping indicates that in man these genes lie in separate conserved DNA segments.
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  P. K. Tucker, R. M. Adkins, and J. S. Rest Differential Rates of Evolution for the ZFY-Related Zinc Finger Genes, Zfy, Zfx, and Zfa in the Mouse Genus Mus Mol. Biol. Evol., June 1, 2003; 20(6): 999 - 1005. [Abstract] [Full Text] [PDF]
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 S. Luoh, P. Bain, R. Polakiewicz, M. Goodheart, H Gardner, R Jaenisch, and D. Page Zfx mutation results in small animal size and reduced germ cell number in male and female mice Development, January 6, 1997; 124(11): 2275 - 2284. [Abstract] [PDF]
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 C M Nagamine, K Chan, L E Hake, and Y F Lau The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues. Genes & Dev., January 1, 1990; 4(1): 63 - 74. [Abstract] [PDF]
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