Zygotic Lethals With Specific Maternal Effect Phenotypes in Drosophila melanogaster. I. Loci on the X Chromosome

INVESTIGATIONS

Zygotic Lethals With Specific Maternal Effect Phenotypes in Drosophila melanogaster. I. Loci on the X Chromosome

N. Perrimon, L. Engstrom and A. P. Mahowald
Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115

In order to identify all X-linked zygotic lethal loci that exhibit a specific maternal effect on embryonic development, germline clonal analyses of X-linked zygotic lethal mutations have been performed. Two strategies were employed. In Screen A germline clonal analysis of 441 mutations at 211 previously mapped X-linked loci within defined regions was performed. In Screen B germline clonal analysis of 581 larval and pupal mutations distributed throughout the entire length of the X chromosome was performed. These approaches provide an 86% level of saturation for X-linked late zygotic lethals (larval and pupal) with specific maternal effect embryonic lethal phenotypes. The maternal effect phenotypes of these mutations are described.

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				S.-W. Oh, T. Kingsley, H.-h. Shin, Z. Zheng, H.-W. Chen, X. Chen, H. Wang, P. Ruan, M. Moody, and S. X. Hou A P-Element Insertion Screen Identified Mutations in 455 Novel Essential Genes in Drosophila Genetics, January 1, 2003; 163(1): 195 - 201. [Abstract] [Full Text] [PDF]

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