Zygotic Lethals With Specific Maternal Effect Phenotypes in Drosophila melanogaster. I. Loci on the X Chromosome

INVESTIGATIONS

Zygotic Lethals With Specific Maternal Effect Phenotypes in Drosophila melanogaster. I. Loci on the X Chromosome

N. Perrimon, L. Engstrom and A. P. Mahowald
Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115

In order to identify all X-linked zygotic lethal loci that exhibit a specific maternal effect on embryonic development, germline clonal analyses of X-linked zygotic lethal mutations have been performed. Two strategies were employed. In Screen A germline clonal analysis of 441 mutations at 211 previously mapped X-linked loci within defined regions was performed. In Screen B germline clonal analysis of 581 larval and pupal mutations distributed throughout the entire length of the X chromosome was performed. These approaches provide an 86% level of saturation for X-linked late zygotic lethals (larval and pupal) with specific maternal effect embryonic lethal phenotypes. The maternal effect phenotypes of these mutations are described.

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				L. M. Galli, T. L. Barnes, S. S. Secrest, T. Kadowaki, and L. W. Burrus Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube Development, September 15, 2007; 134(18): 3339 - 3348. [Abstract] [Full Text] [PDF]

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				G. Sidyelyeva, N. E. Baker, and L. D. Fricker Characterization of the Molecular Basis of the Drosophila Mutations in Carboxypeptidase D: EFFECT ON ENZYME ACTIVITY AND EXPRESSION J. Biol. Chem., May 12, 2006; 281(19): 13844 - 13852. [Abstract] [Full Text] [PDF]

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				K. M. Cadigan and R. Nusse Wnt signaling: a common theme in animal development Genes & Dev., December 15, 1997; 11(24): 3286 - 3305. [Full Text] [PDF]

				X S Hou, E S Goldstein, and N Perrimon Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement. Genes & Dev., July 1, 1997; 11(13): 1728 - 1737. [Abstract] [PDF]

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