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Genetics, Vol 120, 75-81, Copyright © 1988
INVESTIGATIONS |
a/{alpha}-Specific Repression by MAT{alpha}2
J. Strathern, B. Shafer, J. Hicks and C. McGill
Laboratory of Eukaryotic Gene Expression, BRI-Basic Research Program, National Cancer Institute-Frederick Cancer Research Facility, Frederick, Maryland 21701
The product of the MAT{alpha}2 gene is a DNA-binding protein that acts as a repressor of two different sets of cell type-specific genes. In {alpha} cells, the {alpha}2 protein represses the transcription of several a-specific genes. In a/{alpha} cells, the {alpha}2 protein acts together with the product of the MATa1 gene, the a1 protein, to repress several genes used by haploids in the mating process. In addition to the mat{alpha}2 mutations that result in defects in both types of regulation, other mat{alpha}2 alleles have been described that result in defects in the repression of a-specific genes but that do not affect the ability of the {alpha}2 and a1 proteins to interact to repress the haploid-specific genes. We report here the isolation of a new class of mat{alpha}2 mutations that do not affect the ability of the {alpha}2 protein to repress a-specific genes, but that interfere with the ability of the {alpha}2 protein to interact with the a1 protein to repress the haploid-specific genes and establish the a/{alpha} cell type. These mutations may help determine the means by which the a1 protein interacts with {alpha}2 to expand the set of genes under its control.
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