Genetic Evidence That the sans fille Locus Is Involved in Drosophila Sex Determination

INVESTIGATIONS

Genetic Evidence That the sans fille Locus Is Involved in Drosophila Sex Determination

B. Oliver, N. Perrimon and A. P. Mahowald
Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106

Females homozygous for sans fille(1621) (= fs(1)1621) have an abnormal germ line. Instead of producing eggs, the germ-line cells proliferate forming ovarian tumors or excessive numbers of nurse cells. The Sex-lethal gene product(s) regulate the branch point of the dosage compensation and sex determination pathways in the soma. The role of Sex-lethal in the germ line is not clear but the germ line of females homozygous for female sterile Sex-lethal alleles or germ-line clones of loss-of-function alleles are characterized by ovarian tumors. Females heterozygous for sans fille(1621) or Sex-lethal are phenotypically wild type with respect to viability and fertility but females trans-heterozygous for sans fille(1621) and Sex-lethal show ovarian tumors, somatic sexual transformations, and greatly reduced viability.

This article has been cited by other articles:

A. Casper and M. Van Doren
The control of sexual identity in the Drosophila germline
Development, August 1, 2006; 133(15): 2783 - 2791.
[Abstract] [Full Text] [PDF]

L. A. Wrischnik, J. R. Timmer, L. A. Megna, and T. W. Cline
Recruitment of the Proneural Gene scute to the Drosophila Sex-Determination Pathway
Genetics, December 1, 2003; 165(4): 2007 - 2027.
[Abstract] [Full Text] [PDF]

L. O. F. Penalva and L. Sanchez
RNA Binding Protein Sex-Lethal (Sxl) and Control of Drosophila Sex Determination and Dosage Compensation
Microbiol. Mol. Biol. Rev., September 1, 2003; 67(3): 343 - 359.
[Abstract] [Full Text] [PDF]

J. Andrews and B. Oliver
Sex Determination Signals Control ovo-B Transcription in Drosophila melanogaster Germ Cells
Genetics, February 1, 2002; 160(2): 537 - 545.
[Abstract] [Full Text] [PDF]

J Lu and B Oliver
Drosophila OVO regulates ovarian tumor transcription by binding unusually near the transcription start site
Development, January 5, 2001; 128(9): 1671 - 1686.
[Abstract] [PDF]

J. A. Waterbury, J. I. Horabin, D. Bopp, and P. Schedl
Sex Determination in the Drosophila Germline Is Dictated by the Sexual Identity of the Surrounding Soma
Genetics, August 1, 2000; 155(4): 1741 - 1756.
[Abstract] [Full Text]

L. O. F. Penalva, M. F. Ruiz, A. Ortega, B. Granadino, L. Vicente, C. Segarra, J. Valcárcel, and L. Sánchez
The Drosophila fl(2)d Gene, Required for Female-Specific Splicing of Sxl and tra Pre-mRNAs, Encodes a Novel Nuclear Protein With a HQ-Rich Domain
Genetics, May 1, 2000; 155(1): 129 - 139.
[Abstract] [Full Text]

T. W. Cline, D. Z. Rudner, D. A. Barbash, M. Bell, and R. Vutien
Inaugural Article: Functioning of the Drosophila integral U1/U2 protein Snf independent of U1 and U2 small nuclear ribonucleoprotein particles is revealed by snf+ gene dose effects
PNAS, December 7, 1999; 96(25): 14451 - 14458.
[Abstract] [Full Text] [PDF]

I Sahut-Barnola and D Pauli
The Drosophila gene stand still encodes a germline chromatin-associated protein that controls the transcription of the ovarian tumor gene
Development, January 5, 1999; 126(9): 1917 - 1926.
[Abstract] [PDF]

V. Meyer, B. Oliver, and D. Pauli
Multiple Developmental Requirements of Noisette, the Drosophila Homolog of the U2 snRNP-Associated Polypeptide SF3a60
Mol. Cell. Biol., April 1, 1998; 18(4): 1835 - 1843.
[Abstract] [Full Text]

J. Hager and T. Cline
Induction of female Sex-lethal RNA splicing in male germ cells: implications for Drosophila germline sex determination
Development, January 12, 1997; 124(24): 5033 - 5048.
[Abstract] [PDF]

M. Yip, M. Lamka, and H. Lipshitz
Control of germ-band retraction in Drosophila by the zinc-finger protein HINDSIGHT
Development, January 6, 1997; 124(11): 2129 - 2141.
[Abstract] [PDF]

M Mevel-Ninio, E Fouilloux, I Guenal, and A Vincent
The three dominant female-sterile mutations of the Drosophila ovo gene are point mutations that create new translation-initiator AUG codons
Development, January 12, 1996; 122(12): 4131 - 4138.
[Abstract] [PDF]

A Hilfiker, H Amrein, A Dubendorfer, R Schneiter, and R Nothiger
The gene virilizer is required for female-specific splicing controlled by Sxl, the master gene for sexual development in Drosophila
Development, January 12, 1995; 121(12): 4017 - 4026.
[Abstract] [PDF]

R. Nagoshi, J. Patton, E Bae, and P. Geyer
The somatic sex determines the requirement for ovarian tumor gene activity in the proliferation of the Drosophila germline
Development, January 2, 1995; 121(2): 579 - 587.
[Abstract] [PDF]

T W Flickinger and H K Salz
The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein.
Genes & Dev., April 15, 1994; 8(8): 914 - 925.
[Abstract] [PDF]

B Oliver, J Singer, V Laget, G Pennetta, and D Pauli
Function of Drosophila ovo+ in germ-line sex determination depends on X-chromosome number
Development, January 11, 1994; 120(11): 3185 - 3195.
[Abstract] [PDF]

C. Cummings and C Cronmiller
The daughterless gene functions together with Notch and Delta in the control of ovarian follicle development in Drosophila
Development, January 2, 1994; 120(2): 381 - 394.
[Abstract] [PDF]

T. B. Chou, E. Noll, and N. Perrimon
Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras
Development, December 1, 1993; 119(4): 1359 - 1369.
[Abstract] [PDF]

D Pauli, B Oliver, and A. Mahowald
The role of the ovarian tumor locus in Drosophila melanogaster germ line sex determination
Development, January 9, 1993; 119(1): 123 - 134.
[Abstract] [PDF]

D Bopp, J. Horabin, R. Lersch, T. Cline, and P Schedl
Expression of the Sex-lethal gene is controlled at multiple levels during Drosophila oogenesis
Development, January 7, 1993; 118(3): 797 - 812.
[Abstract] [PDF]

B Granadino, P Santamaria, and L Sanchez
Sex determination in the germ line of Drosophila melanogaster: activation of the gene Sex-lethal
Development, January 7, 1993; 118(3): 813 - 816.
[Abstract] [PDF]

S Goode, D Wright, and A. Mahowald
The neurogenic locus brainiac cooperates with the Drosophila EGF receptor to establish the ovarian follicle and to determine its dorsal-ventral polarity
Development, January 9, 1992; 116(1): 177 - 192.
[Abstract] [PDF]

D Bopp, L R Bell, T W Cline, and P Schedl
Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogaster.
Genes & Dev., March 1, 1991; 5(3): 403 - 415.
[Abstract] [PDF]

D M McKearin and A C Spradling
bag-of-marbles: a Drosophila gene required to initiate both male and female gametogenesis.
Genes & Dev., December 1, 1990; 4(12b): 2242 - 2251.
[Abstract] [PDF]

W Mattox, M J Palmer, and B S Baker
Alternative splicing of the sex determination gene transformer-2 is sex-specific in the germ line but not in the soma.
Genes & Dev., May 1, 1990; 4(5): 789 - 805.
[Abstract] [PDF]

H K Salz, E M Maine, L N Keyes, M E Samuels, T W Cline, and P Schedl
The Drosophila female-specific sex-determination gene, Sex-lethal, has stage-, tissue-, and sex-specific RNAs suggesting multiple modes of regulation.
Genes & Dev., May 1, 1989; 3(5): 708 - 719.
[Abstract] [PDF]

				L. A. Wrischnik, J. R. Timmer, L. A. Megna, and T. W. Cline Recruitment of the Proneural Gene scute to the Drosophila Sex-Determination Pathway Genetics, December 1, 2003; 165(4): 2007 - 2027. [Abstract] [Full Text] [PDF]

				L. O. F. Penalva and L. Sanchez RNA Binding Protein Sex-Lethal (Sxl) and Control of Drosophila Sex Determination and Dosage Compensation Microbiol. Mol. Biol. Rev., September 1, 2003; 67(3): 343 - 359. [Abstract] [Full Text] [PDF]

				J. Andrews and B. Oliver Sex Determination Signals Control ovo-B Transcription in Drosophila melanogaster Germ Cells Genetics, February 1, 2002; 160(2): 537 - 545. [Abstract] [Full Text] [PDF]

				J Lu and B Oliver Drosophila OVO regulates ovarian tumor transcription by binding unusually near the transcription start site Development, January 5, 2001; 128(9): 1671 - 1686. [Abstract] [PDF]

				J. A. Waterbury, J. I. Horabin, D. Bopp, and P. Schedl Sex Determination in the Drosophila Germline Is Dictated by the Sexual Identity of the Surrounding Soma Genetics, August 1, 2000; 155(4): 1741 - 1756. [Abstract] [Full Text]

				L. O. F. Penalva, M. F. Ruiz, A. Ortega, B. Granadino, L. Vicente, C. Segarra, J. Valcárcel, and L. Sánchez The Drosophila fl(2)d Gene, Required for Female-Specific Splicing of Sxl and tra Pre-mRNAs, Encodes a Novel Nuclear Protein With a HQ-Rich Domain Genetics, May 1, 2000; 155(1): 129 - 139. [Abstract] [Full Text]

				T. W. Cline, D. Z. Rudner, D. A. Barbash, M. Bell, and R. Vutien Inaugural Article: Functioning of the Drosophila integral U1/U2 protein Snf independent of U1 and U2 small nuclear ribonucleoprotein particles is revealed by snf+ gene dose effects PNAS, December 7, 1999; 96(25): 14451 - 14458. [Abstract] [Full Text] [PDF]

				I Sahut-Barnola and D Pauli The Drosophila gene stand still encodes a germline chromatin-associated protein that controls the transcription of the ovarian tumor gene Development, January 5, 1999; 126(9): 1917 - 1926. [Abstract] [PDF]

				V. Meyer, B. Oliver, and D. Pauli Multiple Developmental Requirements of Noisette, the Drosophila Homolog of the U2 snRNP-Associated Polypeptide SF3a60 Mol. Cell. Biol., April 1, 1998; 18(4): 1835 - 1843. [Abstract] [Full Text]

				J. Hager and T. Cline Induction of female Sex-lethal RNA splicing in male germ cells: implications for Drosophila germline sex determination Development, January 12, 1997; 124(24): 5033 - 5048. [Abstract] [PDF]

				M. Yip, M. Lamka, and H. Lipshitz Control of germ-band retraction in Drosophila by the zinc-finger protein HINDSIGHT Development, January 6, 1997; 124(11): 2129 - 2141. [Abstract] [PDF]

				M Mevel-Ninio, E Fouilloux, I Guenal, and A Vincent The three dominant female-sterile mutations of the Drosophila ovo gene are point mutations that create new translation-initiator AUG codons Development, January 12, 1996; 122(12): 4131 - 4138. [Abstract] [PDF]

				A Hilfiker, H Amrein, A Dubendorfer, R Schneiter, and R Nothiger The gene virilizer is required for female-specific splicing controlled by Sxl, the master gene for sexual development in Drosophila Development, January 12, 1995; 121(12): 4017 - 4026. [Abstract] [PDF]

				R. Nagoshi, J. Patton, E Bae, and P. Geyer The somatic sex determines the requirement for ovarian tumor gene activity in the proliferation of the Drosophila germline Development, January 2, 1995; 121(2): 579 - 587. [Abstract] [PDF]

				T W Flickinger and H K Salz The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein. Genes & Dev., April 15, 1994; 8(8): 914 - 925. [Abstract] [PDF]

				B Oliver, J Singer, V Laget, G Pennetta, and D Pauli Function of Drosophila ovo+ in germ-line sex determination depends on X-chromosome number Development, January 11, 1994; 120(11): 3185 - 3195. [Abstract] [PDF]

				C. Cummings and C Cronmiller The daughterless gene functions together with Notch and Delta in the control of ovarian follicle development in Drosophila Development, January 2, 1994; 120(2): 381 - 394. [Abstract] [PDF]

				T. B. Chou, E. Noll, and N. Perrimon Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras Development, December 1, 1993; 119(4): 1359 - 1369. [Abstract] [PDF]

				D Pauli, B Oliver, and A. Mahowald The role of the ovarian tumor locus in Drosophila melanogaster germ line sex determination Development, January 9, 1993; 119(1): 123 - 134. [Abstract] [PDF]

				D Bopp, J. Horabin, R. Lersch, T. Cline, and P Schedl Expression of the Sex-lethal gene is controlled at multiple levels during Drosophila oogenesis Development, January 7, 1993; 118(3): 797 - 812. [Abstract] [PDF]

				B Granadino, P Santamaria, and L Sanchez Sex determination in the germ line of Drosophila melanogaster: activation of the gene Sex-lethal Development, January 7, 1993; 118(3): 813 - 816. [Abstract] [PDF]

				S Goode, D Wright, and A. Mahowald The neurogenic locus brainiac cooperates with the Drosophila EGF receptor to establish the ovarian follicle and to determine its dorsal-ventral polarity Development, January 9, 1992; 116(1): 177 - 192. [Abstract] [PDF]

				D Bopp, L R Bell, T W Cline, and P Schedl Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogaster. Genes & Dev., March 1, 1991; 5(3): 403 - 415. [Abstract] [PDF]

				D M McKearin and A C Spradling bag-of-marbles: a Drosophila gene required to initiate both male and female gametogenesis. Genes & Dev., December 1, 1990; 4(12b): 2242 - 2251. [Abstract] [PDF]

				W Mattox, M J Palmer, and B S Baker Alternative splicing of the sex determination gene transformer-2 is sex-specific in the germ line but not in the soma. Genes & Dev., May 1, 1990; 4(5): 789 - 805. [Abstract] [PDF]

				H K Salz, E M Maine, L N Keyes, M E Samuels, T W Cline, and P Schedl The Drosophila female-specific sex-determination gene, Sex-lethal, has stage-, tissue-, and sex-specific RNAs suggesting multiple modes of regulation. Genes & Dev., May 1, 1989; 3(5): 708 - 719. [Abstract] [PDF]