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Genetics, Vol 120, 145-157, Copyright © 1988
INVESTIGATIONS |
A Novel Dominant Transformer Allele of the Sex-Determining Gene her-1 of Caenorhabditis elegans
C. Trent, W. B. Wood and H. R. Horvitz
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309
We have characterized a novel dominant allele of the sex-determining gene her-1 of Caenorhabditis elegans. This allele, called n695, results in the incomplete transformation of XX animals into phenotypic males. Previously characterized recessive her-1 alleles transform XO animals into phenotypic hermaphrodites. We have identified five new recessive her-1 mutations as intragenic suppressors of n695. Three of these suppressors are weak, temperature-sensitive alleles. We show that the recessive her-1 mutations are loss-of-function alleles, and that the her-1(n695) mutation results in a gain-of-function at the her-1 locus. The existence of dominant and recessive alleles that cause opposite phenotypic transformations demonstrates that the her-1 gene acts to control sexual identity in C. elegans.
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