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Genetics, Vol 119, 355-363, Copyright © 1988
INVESTIGATIONS |
Identification of a Putative Structural Gene for Cathepsin D in Caenorhabditis elegans
L. A. Jacobson, L. Jen-Jacobson, J. M. Hawdon, G. P. Owens, M. A. Bolanowski, S. W. Emmons, M. V. Shah, R. A. Pollock and D. S. Conklin
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
Mutants of Caenorhabditis elegans having about 10% of wild-type activity of the aspartyl protease cathepsin D have been isolated by screening. Mutant homozygotes have normal growth rates and no obvious morphological or developmental abnormalities. The mutant gene (cad-1) has been mapped to the right extremity of linkage group II. Heterozygous animals (cad-1/+) show intermediate enzyme levels and animals heterozygous for chromosomal deficiencies of the right extremity of linkage group II have 50% of wild-type activity. Cathepsin D purified from a mutant strain has a lower activity per unit mass of pure enzyme. These data suggest that cad-1 is a structural gene for cathepsin D.
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