A Mouse Homeo Box Gene, Hox-1.5, and the Morphological Locus, Hd, Map to Within 1 cM on Chromosome 6

Beverly A. Mock ¹, Lawrence A. D'Hoostelaere ¹, Roberta Matthai ¹, and Konrad Huppi ¹

¹ Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892

Mo-10, a homeo box-containing sequence in the Hox-1 complex of genes referred to as Hox-1.5, was found to be polymorphic in inbred and wild mice, and a strain distribution of three allelic forms of Hox-1.5 are reported. The position of Hox-1.5 was mapped in backcross experiments to within 1 cM of the hypodactyly locus on chromosome 6. This identifies the Hd mutation as a useful model for the examination of homeo box expression during mammalian development.

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