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Substitution Rates Under Stabilizing Selection

Alan Hastings 1

1 Department of Mathematics and Division of Environmental Studies, University of California, Davis, California 95616

Allelic substitutions under stabilizing phenotypic selection on quantitative traits are studied in Monte Carlo simulations of 8 and 16 loci. The results are compared and contrasted to analytical models based on work of M. Kimura for two and "infinite" loci. Selection strengths of S = 4Nes approximately four (which correspond to reasonable strengths of selection for quantitative characters) can retard substitution rates tenfold relative to rates under neutrality. An important finding is a strong dependence of per locus substitution rates on the number of loci.

Submitted on December 3, 1986
Accepted on March 27, 1987






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Copyright © 1987 by the Genetics Society of America.