Chromosome Specificity of Polysomy Promotion by Disruptions of the Saccharomyces cerevisiae RNA1 Gene

Nigel S. Atkinson ¹ and Anita K. Hopper ¹

¹ Department of Biological Chemistry, The M. S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania 17033

Previously, we showed that a disruption of the yeast RNA1 gene with LEU2 sequences promotes polysomy for chromosome XIII. Here we demonstrate that this phenotype is due to sequences specific to the RNA1 gene and that the disruption allele does not affect nondisjunction of three other chromosomes or polysomy of a minichromosome. Hence polysomy appears to be restricted to chromosome XIII.