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- Articles by Song, J. M.
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Allosuppressors that Enhance the Efficiency of Omnipotent Suppressors in Saccharomyces cerevisiae
Jae Mahn Song 1 and Susan W. Liebman 1
1 Department of Biological Sciences, University of Illinois,
Chicago, Illinois 60680
Two recessive Mendelian-allosuppressors have been isolated and
have been shown to enhance the efficiency of omnipotent suppressors thought
to be translational ambiguity mutations. These allosuppressors are unlinked
to each other or to the omnipotent suppressors on which they act. They also
increase the efficiency of the serine-inserting UAA-suppressor, SUP16
. One allosuppressor is allelic or tightly linked to the previously isolated
sal2. Another allosuppressor, called sal6, represents a new
locus, unlinked to the previously isolated sal1-sal5 that enhance
the efficiency of the UAA-suppressors. When present singly in the absence
of suppressors or other modifiers the sal2 and sal6 mutations
do not have suppressor activity. However, when sal2 and sal6
are combined together in a haploid cell they do suppress weakly. In
addition sal2 becomes a weak suppressor in the presence of the [
+] modifying factor.
Accepted on December 5, 1986
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