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GENETIC LOCALIZATION AND ACTION OF REGULATORY GENES AND ELEMENTS
FOR TISSUE-SPECIFIC EXPRESSION OF 
-AMYLASE IN DROSOPHILA MELANOGASTER
A. J. Klarenberg 1, A. J. S. Visser 1, M. F. M. Willemse 1, and W. Scharloo 1
1 Department of Population and Evolutionary Biology, University
of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands
Regulation of tissue-specific 
-amylase (Amy)
expression in Drosophila melanogaster was investigated with a newly
developed method that detects the distribution of -amylase allozymes
in midguts of single adults or third-instar larvae. Trans regulation
was found for -amylase production in the posterior midgut (PMG) of
adults, whereas cis regulation was demonstrated for the larval midgut.
Independent regulation of components of the duplicated Amy locus
was found in larvae. Recombination between the components of the Amy locus
did not result in separation of the putative, very closely linked (less than
0.1 cM) cis-acting regulatory elements for -amylase expression
in the anterior midgut (AMG) of larvae. The expression of one of the components
of the duplicated Amy locus in the AMG of larvae was influenced by
a regulatory gene that was mapped at 2-79.1. -Amylase expression
in the adult PMG was controlled by a trans-acting regulatory gene
localized at 2-79.0, in agreement with the data of Abraham and
Doane.
Accepted on August 20, 1986
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