SEVERAL GALACTOSYLTRANSFERASE ACTIVITIES ARE ASSOCIATED WITH MOUSE CHROMOSOME 17

Kiyoshi Furukawa ¹, Stephen Roth ¹, and Janet Sawicki ²

¹ Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104
² Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104

Indirect evidence suggests that some major histocompatibility complex (MHC) proteins are glycosyltransferases. No sequence or mapping information is available for transferases, although ganglioside variations in mice are linked to the H-2 complex on chromosome 17, and one galactosyltransferase activity on mouse sperm varies with T/t complex genotypes, also on chromosome 17. In the present experiments, diploid and trisomy 17 mouse embryos were assayed for four different galactosyltransferase activities. The same preparations were assayed for isocitrate dehydrogenase (Id-1, chromosome 1) and glyoxalase-1 (Glo-1, chromosome 17). Galactosyltransferase specific activities in trisomy 17 embryos are almost 1.5 times higher than in diploid embryos. The correlation between galactosyltransferase activities and chromosome 17 dosage indicates that the structural or regulatory gene for these enzymes are located on chromosome 17.

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