RECESSIVE NONSENSE SUPPRESSORS IN SACCHAROMYCES CEREVISIAE : ACTION SPECTRA, COMPLEMENTATION GROUPS AND MAP POSITIONS

Bun-Ichiro Ono ¹, Yumiko Ishino-Arao ¹, Masahiro Tanaka ¹, Ikuko Awano ¹, and Sumio Shinoda ¹

¹ Laboratory of Environmental Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700, Japan

Three genes SUP111, SUP112 and SUP113 of Saccharomyces cerevisiae have been identified that can mutate to give recessive omnipotent nonsense suppressors. Alleles of these loci can also act as allosuppressors; that is, different phenotypes, due apparently to different efficiencies of suppression, can result from different alleles at a given locus. The SUP111, SUP112 and SUP113 loci map to the right arms of chromosomes VIII, VII and XIII, respectively.

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