A GLYOXALASE-1 VARIANT ASSOCIATED WITH THE t-COMPLEX IN HOUSE MICE

Joseph H. Nadeau ¹

¹ The Jackson Laboratory, Bar Harbor, Maine 04609

A quantitative variant of glyoxalase-1 associated with the t-complex in house mice is described. GLO-1C in red cell lysates from mice heterozygous for complementing t-haplotypes and from mice homozygous for the t^w8-haplotype had less than one-third the GLO-1 activity of NZB/BINJ, the inbred strain with the lowest activity previously reported. GLO-1C appeared to be determined by the structural locus Glo-1 and, together with two partial t⁶-haplotypes, was used to map Glo-1 to the telomeric portion of the t ⁶-haplotype. Glo-1^c was associated with all t-haplotypes tested and has not been found in mice that lack a t -complex. Thus, this variant of Glo-1^c provides both a further example of gametic disequilibrium between the t-complex and linked loci and a readily identifiable marker for the t-complex.