MOLECULAR MAPPING OF THE ROSY LOCUS IN DROSOPHILA MELANOGASTER

Babette Coté ¹, Welcome Bender ¹, Daniel Curtis ¹, and Arthur Chovnick ²

¹ Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts 02115
² Department of Molecular and Cell Biology, The University of Connecticut, Storrs, Connecticut 06268

The DNA from the chromosomal region of the Drosophila rosy locus has been examined in 83 rosy mutant strains. Several spontaneous and radiation-induced alleles were associated with insertions and deletions, respectively. The lesions are clustered in a 4-kb region. Some of the alleles identified on the DNA map have been located on the genetic map by fine-structure recombination experiments. The genetic and molecular maps are collinear, and the alignment identifies the DNA location of the rosy control region. A rosy RNA of 4.5 kb has been identified; its 5' end lies in or near the control region.

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