- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Weiss, R. B.
- Articles by Gallant, J. A.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Weiss, R. B.
- Articles by Gallant, J. A.
FRAMESHIFT SUPPRESSION IN AMINOACYL-tRNA LIMITED CELLS
Robert B. Weiss 1 and Jonathan A. Gallant 1
1 Department of Genetics, University of Washington, Seattle,
Washington 98195
Under certain conditions aminoacyl-tRNA limitation can phenotypically suppress frameshift alleles. The observed suppression is due to an increase in abnormal translocation of ribosomes translating codons that have a short supply of aminoacyl-tRNA. The rIIB frameshift alleles of bacteriophage T4 are used here to pinpoint the sites of ribosome frameshifting caused by these hypothetical decoding errors. The data indicate that not all hungry codons are associated with abnormal translocation, only a relatively small subset. Analysis of the hungry codons which are associated with ribosome frameshifting points to the existence of severe context effects determining the shiftiness of these codons.
Submitted on July 8, 1985Accepted on December 7, 1985
This article has been cited by other articles:
 |
|
 |
|
  J. URBONAVICIUS, G. STAHL, J. M.B. DURAND, S. N. BEN SALEM, Q. QIAN, P. J. FARABAUGH, and G. R. BJORK Transfer RNA modifications that alter +1 frameshifting in general fail to affect -1 frameshifting RNA, June 1, 2003; 9(6): 760 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. O'Connor Imbalance of tRNAPro isoacceptors induces +1 frameshifting at near-cognate codons Nucleic Acids Res., February 1, 2002; 30(3): 759 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Curran and M Yarus Reading frame selection and transfer RNA anticodon loop stacking Science, December 11, 1987; 238(4833): 1545 - 1550. [Abstract] [PDF]
|
|