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ANALYSIS OF THE DOSAGE COMPENSATION OF A SPECIFIC TRANSCRIPT IN DROSOPHILA MELANOGASTER
Thomas R. Breen 1 and John C. Lucchesi 2
1 Department of Biology, The University of North Carolina, Chapel
Hill, North Carolina 27514
2 Genetics Curriculum, The University of North Carolina, Chapel
Hill, North Carolina 27514
The amount of steady-state level RNA complementary to the X-linked salivary gland secretion polypeptide gene Sgs-4 was measured in male and female third-instar larvae carrying one or two doses of a wild-type allele of the gene. RNA levels were found to be compensated in normal one-dose males and two-dose females and to be dosage-dependent within each sex. The presence of mutant alleles of male-less (mle) was found to reduce the level of Sgs-4 transcripts in males. These results support the contentions that dosage compensation is mediated by regulating the level of X-linked gene transcripts and that a product of the mle+ gene is involved in this process.
Submitted on August 12, 1985Accepted on October 24, 1985
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