SHORT GENE CONVERSIONS IN THE HUMAN FETAL GLOBIN GENE REGION: A BY-PRODUCT OF CHROMOSOME PAIRING DURING MEIOSIS?

Patricia A. Powers ¹ and Oliver Smithies ¹

¹ Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706

DNA sequence comparisons of a 1200-base pair (bp) region in 14 human fetal globin genes in seven linked pairs reveal 31 nucleotide substitutions at positions where the fetal globin genes, G and A, usually differ. In each case, the newly substituted nucleotide is identical to the one found at the same position in the linked nonallelic gene. Most of these nucleotide substitutions are clearly the result of gene conversions, but 11 could be the result of either very short gene conversions or of point mutations. The unexpectedly frequent occurrence of these short gene conversions suggests that they may be the relics of some normal interaction between homologous but nonallelic DNA sequences, and we discuss the possibility that they result from interactions occurring between homologous sequences during the process of meiotic chromosome pairing.

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