SEGREGATION ANALYSES AND GENE-CENTROMERE DISTANCES IN ZEBRAFISH

George Streisinger ¹, Fred Singer ¹, Charline Walker ¹, Donna Knauber ¹, and Nancy Dower ¹

¹ Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403

The gol-1, gol-2, alb-1 and spa-1 mutations affect pigment pattern in the zebrafish. We show here that these loci are unlinked to each other. In addition, gene-centromere distances were determined for these loci by analysis of halftetrads obtained by the inhibition of the second meiotic division. The fractions of tetratype (second-division segregation) tetrads range from 0.24 (spa-1) to 0.89 (gol-1). The observation of >0.67 second-division segregation indicates that the zebrafish has high chiasma interference.

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