GENETIC ANALYSIS OF THE HAIRY LOCUS IN DROSOPHILA MELANOGASTER

P. W. Ingham ¹, S. M. Pinchin ¹, K. R. Howard ¹, and D. Ish-Horowicz ¹

¹ Developmental Genetics Laboratory, Imperial Cancer Research Fund, Mill Hill, London NW7 1AD, England

Mutations of the hairy locus in Drosophila may affect both adult chaeta differentiation and embryonic segmentation. In an effort to understand this phenotypic complexity, we have analyzed 30 mutant alleles of the locus. We find that the alleles fall into four groups according to their complementation properties, suggesting a structurally complex locus in which two distinct functions share a common coding region.

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