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THE LOCUS ENCODING 
A-CRYSTALLIN IS CLOSELY LINKED TO
H-2K ON MOUSE CHROMOSOME 17
Loren C. Skow 1 and Maria E. Donner 1
1 Laboratory of Genetics, National Institute of Environmental
Health Sciences, Research Triangle Park, North Carolina 27709
We have used a complementary DNA (cDNA) for mouse 
A-crystallin
to probe genomic DNA for restriction fragment length polymorphisms which could
be used to map the A-crystallin gene locus (Acry-1) in the
mouse genome. Ten of 12 restriction endonucleases produced fragment polymorphism
among various inbred strains of mice. A comprehensive strain survey conducted
with six endonucleases resulted in the discovery of six allelic forms of
Acry-1. Linkage analysis was conducted on DNA from three sets of recombinant
inbred strains of mice and demonstrated close linkage of Acry-1 with
the major histocompatibility complex (H-2) on chromosome 17.
Analysis of congenic and recombinant congenic strains of mice confirmed the
linkage of Acry-1 and H-2 and located the A gene
to the region between glyoxylase (Glo-1) and H-2K.
Accepted on April 11, 1985
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